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Samenvatting over de Rode bloedcellen $3.75   Add to cart

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Samenvatting over de Rode bloedcellen

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In dit document worden de rode bloedcellen besproken. Het is een samenvatting voor het stuk uit de cursus van pathofysiologie die zich over de rode bloedcellen ontfermt.

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  • January 14, 2022
  • 2
  • 2020/2021
  • Summary
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Samenvatting rode bloedcellen

Hemoglobine (Hb)

Functies:
 Rode kleur bloed
 Transport zuurstof (binding van O2 op Fe in Hb)

Hb met zuurstof = roodachtige kleur, Hb zonder zuurstof = blauwachtige kleur

Affiniteit:
 Omgekeerd evenredig met zuurstofspanning (hoe meer O 2, hoe meer O2 vrijgegeven)
 Afh van pH en CO2 concentratie vh bloed

Barsten bloedcel -> hemoglobine komt vrij -> afbraak tt bilirubine -> geelzucht of icterus

Biconcave “discus” vorm Hemolyse; barsten rode bloedcel
 Bevat geen DNA, enkel Hb Oorzaken => defecten celmembraantransporters of
 Vergroting uitwisselingsoppervlakte defect flexibiliteit
 Flexibiliteit cel verhogen

=> bewaard door celmembraantransporters

Erythropoëse
In beenmerg

Erythropoëtine (EPO); wordt in nieren aangemaakt en stimuleert de aanmaak van rode bloedcellen
Zuurstofsensor (in nieren) => detecteert vermindering O 2 => meer aanmaak EPO
Oorzaken:
 Anemie Prestatievermogen atleten;
 ijle lucht Meer EPO -> meer differentiatie v stamcellen nr
 Ademhalingsmoeilijkheden/ hart en long falen erythrocyten -> meer mogelijkheid tt O2
transport
Verhogen EPO;
 Hoogtestage (ijlere lucht)
 Bloeddoping (bloedtransfusie)
 Toediening EPO
! meer EPO -> meer RBC -> meer viscositeit -> hogere belasting hart ! Nodig voor aanmaak RBC:
 Ijzer; synth. Hb
 Vitamine B12 en foliumzuur; productie erythrocyten
 Intrinsieke factor; opname B12




Parameters
 Hematocriet

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