Class notes
Haemostasis
- Course
- Institution
Lectures notes on Haemostasis
[Show more]
Seller
Follow
polinalobacheva
Reviews received
Content preview
Haemostasis II - Coagulation and secondary haemostasisSecondary haemostasis:
- Platelet plug alone is not enough to stem the blood loss
- Needs to be reinforced
- This is where the coagulation pathways come into play
- Secondary haemostasis (coagulation) is usually initiated simultaneously with primary haemostasis upon
endothelial damage
- Result of activation of coagulation pathways is that soluble fibrinogen is converted to insoluble fibrin
Coagulation cascade - key complexes: Coagulation factors:
Coagulation Cascade:
- Circulating inactive zymogens are
sequentially activated to the
active enzyme forms
- Intrinsic pathway – requires
enzymes and factors all present in
the plasma.
- Extrinsic pathway- requires
enzymes and factors present in
the plasma as well as an activator
- Both pathways converge on a
common pathway to generate the
fibrin clot
, Events of coagulation:
1. Endothelial injury exposes tissue factor (TF) – factor which
binds its circulating ligand in plasma, the pro-enzyme FVII
2. Binding to TF activates FVII and promotes activity
3. The TF-FVIIa complex then activates the pro-enzyme FX
4. FXa is able to cleave its substrate prothrombin (FII) to
thrombin
5. Only a small amount of FXa is generated by this reaction
Extrinsic pathway:
1. FXa + FVa
2. Need phospholipids (PL) and Ca2+ ions
3. This is the prothrombinase complex
4. It is able to cleave its substrate prothrombin (FII) to thrombin
5. Only small amounts of thrombin are generated by this
reaction
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller polinalobacheva. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $13.05. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
67232 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now