Summary
Summary moleculaire celbiologie (D013083A)
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, LES 1 ( H1)•
Qua
sIng = baat verspreiden pas licht
.
bepaald product hoog genoeg
wanneer conc
is
u .
signaalmolecule
✗ Parochie ^
•
NO =
Mikstofmonoxide ( EDRF) → effect
→ auto uien
•
werking NO
A-25 → e NOS →
mg → NO (+ citwlline) → gvany laat cyuase ( GTP → CGNP)
CGMP → PKG → toe myosine Light Chain sortatan
.
→ delon myosine lichte
keten
relaxatie gladde spiercel prim + Dec .
boodschappen
•
negatieve regulatie , 1) CGMP foto dieMerase 1 CGMP → GMP
e) NO → instabiel
• contractie ,
myosine Light Chain kinase
•
vb .
Sildenafil citaat , -1 CGMP fopodiemerase → extra relaxatie
IJ
, LES 2 ( H1 ) : GPCRD : ( na) adrenaline
•
mgmpatisch zenuwstelsel →
hartslag bloeddruk , ,
adem îî
→ np sverlening te
→ vet → veteranen
→ glycogeen → glucose
• ( na) adrenaline = catecholamines
↳
ligand voor adrenerge receptoren
L-
Tip → DOPA ( catecheet groep ) →
dopamine → (na) adrenaline
+ OH
-
COO
-
+ Oh ↳
+ CH }
noradrenaline adrenaline
te lv
neurotransmitter hormoon
roymp .
zenuw uit .
b niermerg
←
→
endocrien
• redundantie + preiotnopie
t te
2 = effect # functies
✗
× adhenergei vasoconstrictie
•
adrenerge receptoren
→ B adrenerge , vaso dilatatie
GPCR
GPCR → NHÌ extracell ; COO intrad ; 7 helices hand
-
•
→ bindt G- eiwit
•
G- eiwit → ✗
, B 8 Mb eenheid
,
→ ligandbinding → metrumw zigingen → binding
GPCRT G- eiwit → GTP b ✗ → rowitchIs I → ✗ Ipv →✗ los v. GPCR
amplificatie
→✗
op adeny laat cyclase → CAMP / pr → ionkanalen
amplificatie
CAMP AMP
negatieve regulatie →
•
:
CAMP fotodiemenAR
ijij
ijij
, •
deactivatie G- eiwit , Ga GTP → Ga GDP → Ga pìr → deactivatie
•
3 eigenschappen 1) t d , GT Pax activiteit v. ✗
2) amplificatie
3) uitdovend
zelf
-
•
CAMP → PRA → celkern → ⑧ CREB → binding promoten → CBP →
ff transcriptie
pheiokap
•
glucose vr stellen door adrenaline via CAMP
om • Geen mmthase (PO) → gin glycogeen
✗ nrprlhese
aan → (Anp → pra
1) fonorylan kinase (PO) → glycogeen had (④ .
gwcoxthr mell en
•
CAMP effect → als pecigiek
→ CAMP → PRA → inh kinase
fosfatase }
•
von NO roignaalb aan , .
""
→ CGMP → PKG → act .
•
AKAP → beperking CANP effect in cel
→ verankering PKA
ijij ij
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