This fact sheet will explain all you need to know regarding the safe administration of Diclofenac including dosage, pharmacodynamics, side effects, interactions, contraindications and administration. Perfect for student midwives!
• Fatigue / Irritability • Cardiac, hepatic or renal impairment
INTERATIONS: • Clotting disorders
• Antihypertensives - increased effect
• Anti-coagulants
PHARMACODYNAMICS: FETAL/BREASTFEEDING RISK:
• Inhibits the enzyme cyclo-oxygenase • Benefits must outweigh the risk and the
which = reduction in prostaglandin lowest possible effective dose should be
synthesis use
• Absorbed through membranes in the anus • Can cause closure of PDA in utero,
and goes straight to systemic circulation persistent pulmonary hypertension
• Eliminated 60% via urine, 40% faeces • The amount secreted too small to be
considered harmful - limited evidence -
manufacturer says toa avoid
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