Assignment 1
56051735
Unique number 682975
BCH 3702
Question 1
(a)
1. Adipose: Fatty acid synthesis: Pathway is slower.
2. Muscle: Glycolysis, fatty acid synthesis, and glycogen synthesis:Pathway is slower.
3. Liver:
● Glycolysis - Pathway is faster
● gluconeogenesis, glycogen synthesis, and fatty acid synthesis -Pathway is
slower
● pentose phosphate pathway - Pathway is unchanged
b)
1. Adipose and Liver: fatty acid synthesis is slower as a result of insufficient amount
of insulin leading to the acetyl-CoA carboxylase being inactive. Acetyl-CoA carboxylase
is the first enzyme to catalyse and moderate the fatty acid synthesis. Glycogen
synthesis inhibited by adenylyl cyclase phosphorylation of glycogen synthase and in
doing leading to its activation.
2. Muscle: glycolysis is slower for the reason that Glucose transporter type 4 is
inactive, so the uptake of glucose absorption is prevented
3. Liver: glycolysis is slower or the reason that the phosphofructokinase-2 (a key
enzyme of gluconeogenesis that catalyzes the hydrolysis of fructose 1,6-bisphosphate
to fructose 6-phosphate)is turned to the form with active fructose bisphosphatase 2,
reducing fructose 2,6-bisphosphate, which allosterically trigger phosphofructokinase
and prevent fructose bisphosphatase 1. In so doing glycogenesis is also initiated.
Question 2
Anaerobic glycolysis is when glucose is transformed to lactate to produce energy when
there is a limited amount of oxygen available in muscles. Anaerobic glycolysis is not
really wasteful because during the cori cycle,lactate produced by anaerobic glycolysis
in the muscles moves to the liver and gluconeogenesis converts lactate to glucose.
Pyruvate can then be oxidized when oxygen levels are sufficient by cellular respiration .
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