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Complete samenvatting Klinische psychiatrie

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Complete samenvatting van het vak Klinische psychiatrie, academiejaar , prof. Dirk Van West aan de VUB. De 10 lessen zijn samengevat op basis van de slides, uitleg tijdens de les & samenvattingen van vorige jaren. Inclusief aanduiding (in het groen) van welke onderdelen hij vorige jaren heeft ...

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  • January 30, 2022
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Klinische psychiatrie
SAMENVATTING VUB
EMMA VANNESTE

,Inhoud
1. gebruik van de DSM-V ........................................................................................................................ 7
1.1 inleiding ........................................................................................................................................ 7
1.1.1 psychopathologie................................................................................................................... 7
1.1.2 psychiatrische stoornis .......................................................................................................... 7
1.2 classificatie.................................................................................................................................... 8
1.2.1 algemeen ............................................................................................................................... 8
1.2.2 DSM/ICD ................................................................................................................................ 9
1.2.3 voor- en nadelen.................................................................................................................... 9
1.3 diagnostiek.................................................................................................................................... 9
1.4 globale veranderingen DSM-V .................................................................................................... 10
1.5 opzet DSM-V ............................................................................................................................... 10
1.6 stellingen .................................................................................................................................... 11
2. inleiding ............................................................................................................................................ 12
2.1 inleiding ...................................................................................................................................... 12
2.1.1 normaliteit en psychopathologie ......................................................................................... 12
2.1.2 probleem met subjectiviteit ................................................................................................ 12
2.1.3 epidemiologie ...................................................................................................................... 13
2.2 geschiedenis van de psychiatrie ................................................................................................. 13
2.3 etiopathogenese ......................................................................................................................... 14
2.3. fysiopathogenese....................................................................................................................... 14
2.3.1 genetica ............................................................................................................................... 14
2.3.2 heritabiliteit ......................................................................................................................... 14
2.3.3 gen-omgeving-gen ............................................................................................................... 14
2.3.4 neurotransmitters................................................................................................................ 15
2.4 Psychopathogense ...................................................................................................................... 15
2.4.1 psychologisch perspectief: niet te kennen .......................................................................... 15
2.4.2 psychische functies .............................................................................................................. 15
2.4.3 stoornis in het psychisch functioneren ................................................................................ 16
2.4.4 psychiatrisch onderzoek ...................................................................................................... 17
2.4.4 beeldvorming ....................................................................................................................... 18
3. neurocognitieve stoornissen ............................................................................................................ 19
3.1 algemeen .................................................................................................................................... 19
3.1.1 het geheugen ....................................................................................................................... 19
3.1.2 neurocognitieve testen ........................................................................................................ 19
3.1.3 Wat is een normaal ouderdomsproces? .............................................................................. 20

, 3.2 dementie..................................................................................................................................... 20
3.2.1 algemeen ............................................................................................................................. 20
3.2.2 klinische kenmerken Alzheimer ........................................................................................... 20
3.2.3 Indeling ................................................................................................................................ 22
3.2.3 ziekte van alzheimer, prognose ........................................................................................... 22
3.2.4 vasculaire dementie............................................................................................................. 22
3.2.5 fronto-temporale dementie ................................................................................................ 22
3.2.6 diagnostiek dementie .......................................................................................................... 23
3.2.7 dementie-depressie ............................................................................................................. 23
3.2.8 Behandeling dementie......................................................................................................... 24
3.2.8 Behandeling psychiatrische symptomen (medicijnen niet te kennen) ................................ 24
3.3 delirium....................................................................................................................................... 25
3.3.1 klinische kenmerken DSM ................................................................................................... 25
3.3.2 subtypes............................................................................................................................... 25
3.3.3 delirium-depressie-dementie .............................................................................................. 25
3.3.4 oorzaken delier: I WATCH DEAD .......................................................................................... 25
3.3.5 behandeling ......................................................................................................................... 26
3.4 amnestische stoornissen ............................................................................................................ 26
4. middelengerelateerde en verslavingsstoornissen ............................................................................ 26
4.1 stoornissen in het gebruik .......................................................................................................... 26
4.1.1 misbruik van een middel: DSM ............................................................................................ 26
4.1.2 middelenafhankelijkheid ..................................................................................................... 27
4.2 stoornissen door het gebruik...................................................................................................... 27
4.2.1 intoxicatie door een middel ................................................................................................. 27
4.2.2 onthouding van een middel ................................................................................................. 27
4.3 psychoactieve stoffen ................................................................................................................. 27
4.3.1 algemeen ............................................................................................................................. 27
4.3.2 alcoholgebruik ..................................................................................................................... 28
4.4 middelengerelateerde en verslavingsstoornissen ...................................................................... 29
4.4.1 diagnostiek........................................................................................................................... 29
4.4.2 etiopathogenese .................................................................................................................. 29
4.4.3 progose ................................................................................................................................ 29
4.4.3 behandeling - algemeen ...................................................................................................... 30
5. schizofrenie en andere psychotische stoornissen ............................................................................ 31
5.1 schizofrenie................................................................................................................................. 31
5.1.1 klinische criteria ................................................................................................................... 31

, 5.1.2 kenmerken ........................................................................................................................... 31
5.1.3 differentiële diagnostiek ...................................................................................................... 33
5.1.4 epidemiologie ...................................................................................................................... 34
5.1.6 Ethiopathogenese: stresskwetsbaarheidsmodel ................................................................. 34
5.1.5 prodromen ........................................................................................................................... 34
5.1.6 genetische factoren ............................................................................................................. 35
5.1.7 preventie.............................................................................................................................. 36
5.1.8 behandeling ......................................................................................................................... 36
5.1.9 beloop .................................................................................................................................. 37
5.2 verwante stoornissen ................................................................................................................. 38
5.2.1 schizofreniforme stoornis .................................................................................................... 38
5.2.2 schizoaffectieve stoornis ..................................................................................................... 38
5.2.3 waanstoornis ....................................................................................................................... 38
5.2.4 kortdurende psychotische stoornis ..................................................................................... 39
5.2.5 gedeelde psychotische stoornis ........................................................................................... 39
6. stemmingsstoornissen ...................................................................................................................... 39
6.1 unipolaire stemmingsstoornissen............................................................................................... 39
6.1.1 depressieve stoornis ............................................................................................................ 39
6.1.2 dysthyme stoornis ............................................................................................................... 40
6.1.3 andere.................................................................................................................................. 40
6.2 bipolaire stemmingsstoornissen ................................................................................................. 41
6.2.1 Manische episode (type I).................................................................................................... 41
6.2.2 hypomane episode (type II) ................................................................................................. 41
6.2.3 cyclothyme stoornis ............................................................................................................. 42
6.2.4 andere.................................................................................................................................. 42
6.3 gemende episode ....................................................................................................................... 42
6.4 Manisch (bipolair) vs. Depressief (unipolair) .............................................................................. 42
6.4 diagnostiek en Comorbiditeit ..................................................................................................... 43
6.5 epidemiologie ............................................................................................................................. 43
6.6. Etiopathogenese en fysiopathogenese...................................................................................... 43
6.7 etiopathogenese en psychopathogenese ................................................................................... 44
6.8 behandeling ................................................................................................................................ 44
6.8.1 psychotherapie .................................................................................................................... 45
6.8.2 psychofarmaca..................................................................................................................... 45
.......................................................................................................................................................... 46
6.9 suïcidaal proces .......................................................................................................................... 46

, 6.9.1 ontremmende factoren ....................................................................................................... 46
6.9.2 beschermende factoren....................................................................................................... 46
6.9.3 Waarschuwingssignalen (niet besproken tijdens de les) ..................................................... 46
7. angststoornissen ............................................................................................................................... 47
7.1 inleiding ...................................................................................................................................... 47
7.2 angststoornissen ......................................................................................................................... 47
7.2.1 cerebraal hersen-angstcircuit .............................................................................................. 47
7.2.2 behandeling ......................................................................................................................... 47
7.3 soorten angststoornissen ........................................................................................................... 48
7.3.1 specifieke of enkelvoudige fobieën ................................................................................... 48
7.3.2 paniekstoornis ..................................................................................................................... 49
7.3.3 agorafobie............................................................................................................................ 49
7.3.4 sociale fobie ......................................................................................................................... 50
7.3.5 obsessief-impulsieve stoornis (OCD) ................................................................................... 51
7.3.6 gegeneraliseerde angststoornis (GAS) ................................................................................. 51
7.3.7 posttraumatische stressstoornis (PTSD/PTSS) ..................................................................... 52
7.3.8 acute stresstoornis .............................................................................................................. 53
7.4 Angststoornissen: epidemiologie............................................................................................... 53
8. eetstoornissen .................................................................................................................................. 54
8.1 Anorexia nervosa ........................................................................................................................ 54
8.1.1 klinische kenmerken ............................................................................................................ 54
8.2 bulimia nervosa .......................................................................................................................... 54
8.2.1 klinische kenmerken ............................................................................................................ 54
8.2.2 eetstoornissen: diagnostiek ................................................................................................. 55
8.2.3 etiopathogenese .................................................................................................................. 56
8.2.4 behandeling ......................................................................................................................... 56
9. ontwikkelingsstoornissen ................................................................................................................. 57
9.1 ADHD .......................................................................................................................................... 57
9.1.1 klinische kenmerken ............................................................................................................ 57
9.1.2 ontwikkelingspathologie ...................................................................................................... 57
9.1.4 classificatie........................................................................................................................... 58
9.1.5 epidemiologie ...................................................................................................................... 59
9.2 ASS .............................................................................................................................................. 59
9.2.1 klinische kenmerken ............................................................................................................ 59
9.2.2 screening.............................................................................................................................. 60
9.2.3 epidemiologie ...................................................................................................................... 61

, 9.2.4 etiopathogenese en fysiopathogenese................................................................................ 61
9.2.5 etiopathogenese en psychopathogenese ............................................................................ 61
9.2.5 behandeling ......................................................................................................................... 62
10. gedragsstoornissen ......................................................................................................................... 63
10.1 externaliserende stoornissen ................................................................................................... 63
10.1.1 oppositionele-opstandige stoornis (ODD) ......................................................................... 63
10.1.2 normoverschrijdend gedragsstoornis (conduct disorder) ................................................. 63
10.1.3 epidemiologie .................................................................................................................... 64
10.1.4 etiopathogenese ................................................................................................................ 65
10.1.5 preventie............................................................................................................................ 66
10.1.6 Behandeling ....................................................................................................................... 66
11. slaapstoornissen ............................................................................................................................. 67
11.1 het slaapproces......................................................................................................................... 67
11.2 dyssomnia ................................................................................................................................. 68
11.2.1 primaire insomnia .............................................................................................................. 68
11.2.2 primaire hypersomnia ....................................................................................................... 68
11.2.3 narcolepsie ........................................................................................................................ 68
11.2.4 slaapgebonden ademhalingsstoornissen........................................................................... 69
11.2.5 slaapstoornissen gebonden aan de circadiaanse ritmiek .................................................. 69
11.2.6. Dyssomnia Niet Anderszins Omschreven (dit is een soort restcategorie) ........................ 70
11.3 parasomnia ............................................................................................................................... 70
11.3.1 nachtmerries...................................................................................................................... 70
11.3.2 pavor nocturnus................................................................................................................. 71
11.3.3 slaapwandelen ................................................................................................................... 71
(11.3.4 behandeling ) .................................................................................................................... 72
11.4 Insomnia/hypersomnia in samenhang met een psychiatrische stoornis ................................. 72
12. seksuele stoornissen ....................................................................................................................... 72
12.1 seksuele disfuncties .................................................................................................................. 72
12.1.1 De seksuele respons cyclus ................................................................................................ 72
12.1.2 algemene kenmerken ........................................................................................................ 73
12.1.3 stoornis in het seksuele verlangen .................................................................................... 73
12.1.4 seksuele opwindingsstoornissen ....................................................................................... 73
12.1.5 orgasmestoornissen........................................................................................................... 74
12.1.6 seksuele pijnstoornissen .................................................................................................... 74
12.1.7 diagnostiek......................................................................................................................... 74
12.1.8 etiopathogenese & behandeling ....................................................................................... 75

, 12.2 parafilie ..................................................................................................................................... 75
12.2.1 drangstoornis ..................................................................................................................... 75
12.2.2 behandeling ....................................................................................................................... 77
13. persoonlijkheidsstoornissen ........................................................................................................... 77
13.1 Algemeen à indeling niet kennen, wel weten dat het categoriaal / prototypische indeling is77
13.1.1 Kenmerken......................................................................................................................... 78
13.2 cluster A .................................................................................................................................... 78
13.2.1 Algemeen ........................................................................................................................... 78
13.2.2 Paranoïde persoonlijkheidsstoornis .................................................................................. 78
13.2.3 Schizoïde persoonlijkheidsstoornis.................................................................................... 79
13.2.4 Schizotypische persoonlijkheidsstoornis ........................................................................... 79
13.3 cluster B .................................................................................................................................... 79
13.3.1 Algemeen ........................................................................................................................... 79
13.3.2 antisociale persoonlijkheidsstoornissen ............................................................................ 80
13.3.3 borderline persoonlijkheidsstoornissen ............................................................................ 80
13.3.4 theatrale persoonlijkheidsstoornissen .............................................................................. 80
13.3.5 narcistische persoonlijkheidsstoornissen .......................................................................... 81
13.4 cluster C .................................................................................................................................... 81
13.4.1 algemeen ........................................................................................................................... 81
13.4.2 Ontwijkende persoonlijkheidsstoornis .............................................................................. 81
13.4.3 Afhankelijke persoonlijkheidsstoornis ............................................................................... 82
13.4.3 Obsessieve-compulsieve persoonlijkheidsstoornis............................................................ 82
13.5 Prevalentie`............................................................................................................................... 82
13.6 Ontwikkeling, beloop, gevolgen ............................................................................................... 83
13.7 Diagnostiek ............................................................................................................................... 83
13.8 Diagnostische instrumenten - niet te kennen.......................................................................... 83
13.9 Comorbiditeit / differentiële diagnostiek ................................................................................. 83
13.10 Etiopathogenese ..................................................................................................................... 83
13.11 Behandeling ............................................................................................................................ 84

,1. gebruik van de DSM-V

1.1 inleiding

1.1.1 psychopathologie
• = ‘Wetenschap of studie van het geestelijk of psychisch lijden’
• Twee benaderingen:
o Syndroombenadering: psychologie van het pathologische (gegroepeerde entiteiten):
samenhangend geheel van klachten en symptomen. (DSM-V)
o Symptoombenadering: pathologie van het psychische (algemene psychische processen
of functies), communiceren met cliënt
• Twee typen diagnosen:
o Syndroomdiagnose of descriptieve diagnose: deze diagnose is alleen beschrijvend en
geeft geen informatie over de redenen en manier van ontstaan
o Structuurdiagnose: deze diagnose geeft naast een beschrijving van de symptomatologie
aan waardoor en op welke wijze het syndroom ontstaan is (m.a.w. niet enkel een
diagnose)
§ Factoren die iemand kwetsbaar maken
(predisponerende of voorbeschikkende factoren)
§ Factoren die de stoornis uitlokken
(precipiterende of uitlokkende factoren)
§ Factoren die de stoornis onderhouden
(perpetuerende of onderhoudende factoren)

1.1.2 psychiatrische stoornis
• ‘Abnormaal’ verschijnsel
o Afwijkend van de sociale norm of van wat in de cultuur als ‘normaal’ gedrag geldt.
o Veroorzaakt ongemak, lijden of bezorgdheid bij de betrokkene en/of de omgeving
• Medisch model (‘disease’)
o Etiologie (ontstaan)
o Oorzakelijke factoren (predispositie)
o Uitlokkende factoren (precipitatie)
o In standhoudende factoren (perpetuatie)
o Pathogenese (ontwikkeling)
o Prognose (natuurlijk beloop)
o Behandeling (Preventie/Therapie)
• Psychologisch model
o Ziektebeleving (‘illness’)
• Sociologisch model
o Ziekterol
o Alle factoren die niet per se vast staan verklaren samen de ziekte
• Klinische psychiatrie = care, quality of life

, • Bio-psycho-sociaal model




Kwetsbaarheid ó resilience of veerkrachtigheid

1.2 classificatie

1.2.1 algemeen
• Doel:
o Orde scheppen
o Fenomenen groeperen
o Gemeenschappelijke taal ontwikkelen
• Ideaal:
o Perfecte representatie van onderliggende realiteit en diversiteit
o Voorspelt verloop, oorzaken, reacties op behandeling
• Nuttig:
o Communicatiemiddel
o Registratiemiddel
• Kritiek: men kan enkel diagnoses stellen, men kan met een classificatie nooit verklaren.

Cut-off waarde volgens DSM-V




• Categoriaal: dichtomen pathologieën
• Dimensionaal: spectrum benadering DSM-V
• Profielbeschrijving of prototypisch: bv. persoonlijkheidsstoornissen a.d.v. traits
• * = onderdeel psychiatrie waarin behandeling afhangt van ernst stoornis

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