Human Parasites, Micro-organisms And Zoonoses (2008FBDBMW)
Summary
Summary of all drug treatments Human parasites, micro-organisms and zoonoses
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Course
Human Parasites, Micro-organisms And Zoonoses (2008FBDBMW)
Institution
Universiteit Antwerpen (UA)
Book
Human Parasitology
This document contains all different drug treatments WITH explanation that need to be known for the course of Human parasites, micro-organisms and zoonoses
of the first Master's year of Biomedical Sciences: Infectious and Tropical Diseases.
Only contains the different drug treatments seen in class.
February 1, 2022
4
2021/2022
Summary
Subjects
drugs
drug treatment
drug treatments
biomedical sciences
tropical diseases
human parasites
human parasitology
human parasites
protozoa
infectious and tropical diseases
micro organisms and zoonoses
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Human Parasites, Micro-organisms And Zoonoses (2008FBDBMW)
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Drug treatments Human Parasites and Zoonoses
Part 2: protozoa
Parasite Drug Notes
E. histolytica Luminal action:
- Idoquinol, diiodohydroxyquin Competes for iron in GIT
- Paromomycin Interferes w/ protein synth.
Systemic action:
- (Dihydro-)emetine For pregnant women
- Chloroquine Interferes w food vacuole & digestion of RBC
Luminal + systemic action:
- Nitro-imidazoles (metronidazole) Prod. of ROS & mutagenic to parasite
B. coli Metronidazole Prod. of ROS & mutagenic to parasite
G. intestinalis Metronidazole Prod. of ROS & mutagenic to parasite
T. vaginalis Metronidazole Prod. of ROS & mutagenic to parasite
T. brucei Suramin: stage 1 Polysulfonated naphthylamine: inhibition of
rhodesiense - Haemo-lymphatic stages, cidal glycolysis
Melarsoprol: stage 2 Inhibits glycolysis
- Arsenic derivate: 5-10% mortality
T. brucei Pentamidine: stage 1 Inhibits DHF-reductase: folate pathway
gambiense - Haemo-lymphatic stages, cidal (protection against ROS)
Eflornithine / DFMO: stage 2
- Often combinated with Inhibits ornithine-decarboxylase: polyamine
Nifurtimox (NECT): preferred synthesis (ROS)
treatment Gambiense stage 1 & 2
Fexinidazole: both stages Oral drug: no hospitalization
- Very late stage: better NECT Activation by nitro-reductase: induces DNA
- Chance of resistance damage.
T. cruzi Etiological: nifurtimox or benznidazole Nifurtimox: GI not well tolerated
Symptomatix: analgetics, corticosteroids, Benznidazole: nitro-imidazole
B-blockers
Leishmania Pentavalent antimony Lot of resistance in India. Depletes parasite
of glutathiones (protects them from ROS)
Miltefosine: oral treatment! Oral treatment. Interferes with
- High relapse numbers mitochondrial activity.
Amphotericin-B = drug of choice at this Binds ergosterol in lipid membrane: disturbs
moment (cold chain needed). Actually an integrity. Esp. useful as liposome: more
antifungal drug accumulation in macrophage. Cells in bone
marrow not necessary targeted: some
parasites may remain
Paromycin Interferes with protein synthesis
Pentamidine Interrupts folic pathway
Allopurinol Veterinary importance in dogs. Treatment
for life for dogs.
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