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Final Draft of Presentation Biochemistry Symposia (6012BCBMOL)
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Micro RNA and Wound HealingINTODUCTION RESULTS
Micro RNA’s (miRNA) are small non-coding proteins about Dynamic miRNome changes during the inflammatory
22-nt long. Their functions are based around the phase of human skin wound healing.
degradation of mRNA and post-translational gene miR-132 expression is induced by TGF-β in
modifications. Here Li, et al analyse the role of miRNA keratinocytes.
within wound healing. Characterization of the transcriptome regulated by
During the inflammatory phase of wound healing epidermal miR-132 in keratinocytes.
miR-132 suppresses keratinocyte chemokine
keratinocytes induce the release of inflammatory cytokines
production by regulating the NF-κB pathway.
such as CXC chemokine ligand 1 (CXCL1) and IL-8.
miR-132 promotes keratinocyte growth by regulating
miRNA-132 has been shown to be a major molecular STAT3 and ERK pathways.
regulator in human keratinocytes with a crucial role in HB-EGF is targeted by miR-132 in keratinocytes.
facilitating the shift from the inflammatory phase to the Lack of miR-132 delays skin wound healing in vivo.
proliferation phase. Inhibition of miR-132 delays reepithelialisation of
human ex vivo skin wounds.
CONCLU
miRNA-1
healing c
growth f
driving fa
in increa
colleagu
OBJECTIVES overexpr
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