Other
Revision notes for 6103BCBMOL exam
- Course
- Institution
Notes for personalised medicine, with questions about issues/impact of tailored healthcare.
[Show more]
Seller
Follow
phoebe1
Content preview
Personalised medicineGenetics play an important role in disease susceptibility
Genetic variation affects gene expression or function and hence pharmacology and drug effect
Genes that influence disease susceptibility or progression can affect drug effect
Pharmacodiagnostics A.K.A theranostics
Pharmacogenomics – take a patient’s blood sample, look at their genetic variations determine which
variations may cause adverse drug reactions or limited potency and prescribe a drug that will be
effective to them – can also help to predict correct dosing not just which drug to use
“As an example, if a company knows ahead of time that someone has a genetic variation that will cause an
adverse reaction to a drug or that will make a drug ineffective, those patients can be excluded from the clinical
trial. This may speed up the clinical trial process and target the specific population that can be helped by any
one medication.” - Vogenberg, F. R., Isaacson Barash, C., & Pursel, M. (2010). Personalized
medicine: part 1: evolution and development into theranostics. P & T : a peer-reviewed journal for
formulary management, 35(10), 560–576.
- Interesting comment to make, if those people are excluded this poses a risk of someone
prescribed a drug by a GP that has not done the correct tests or is not properly educated this
could be catastrophic – people with genetic variations should be included if the drug dosage
can be tailored to their genetic variation
Concerns
How reliable are the tests?
Are health care providers prepared to use this information?
Will Insurance companies pay for the tests?
Will tailor made medicine lead to discrimination?
Will ethnic biases in science bias treatment developments?
Will this affect people’s privacy?
Case studies
https://www.sciencedirect.com/science/article/abs/pii/S2468125319303401
- Crohns disease
Samec, M., Liskova, A., Koklesova, L. et al. Flavonoids against the Warburg
phenotype—concepts of predictive, preventive and personalised medicine to cut
the Gordian knot of cancer cell metabolism. EPMA Journal 11, 377–398 (2020).
https://doi.org/10.1007/s13167-020-00217-y
- Anticancer therapy targeting Warburg effect
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller phoebe1. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $7.42. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
76710 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now