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Samenvatting ziektemechanismen Bammens

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Uitgebreide samenvatting ziektemechanismen deel professor Bammens. Samenvatting omvat alle relevantie info uit slides, cursus en lessen. Ook de casussen staan erin uitgewerkt.

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  • February 7, 2022
  • 71
  • 2021/2022
  • Summary
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Nat balans : nieren 7rem en









Nat filtratie 25500mmol /
:
dag
Nat reabsorptie 25400mmol /
dag
:




213 in PT ,
Rest vooral in lus v Hen te
• PT : transcllluloeir :
apicaal Cottonsport ( oa NHE ) =
passief
iso om
basdateraal
-




Nak =
actief

paracellulair eten
: ,


graaien +


TAL : transcelluloiir :
apicaal Nak 24 2 NHE
hyperosm baso lateraal Nak
backleak
para cellulair : enkel eten .




gradiënt .






DCT : transcelwlair :
apicaal Nau oéhan sporter
hyperosm basolateraal Nak
niet
paracelwlairlondoorgan.net u)




(CT / MCD : ENal apicaal
Na / kbasaat .




wo mnd /
Na excretie
dag
:


.

beperkt maar wel balans in ✗ Uit




ij

, NA BALANS :




4 PARALLELLE EFFECTOR
PATHWAYS :




RAAS
stimulator en Renirie vr zetting
ONDER VULLING
& de W


< Naa
aan ⑤ symp . barok functie
Mac d . .
atf art
.




& &


REN IN E
VR ZETTING
Effect Renirie



Renirie w door JGA vr gezet als volume &
te


angiot geen .
-
>
ong& ACE .
I ( in circulatie )

I
ongI .




④ b nier om aldosteron vr te zetten


Effect aldosteronen
aldosteron e : DT , CCT MCT
,
:
Principal cells



}
-
>
⑦ ENal apicaal
→ kt kanalen apicaal ④ Na reabsorptie

⑤ Nak


ij
ijijijIJ

, Aldosteron e escape
' '
aan effect aldosterone b aanhoudende aldosterone
ontsnappen v.
prod

aanpassen met nieuw evenwicht tot
gevolg
=




extra zout in lichaam - >
v01 in → BPA →
filtratie te → zoutexcretie 1




M¥ Efcv moet voldoende z n om excretie te doen
st gen
als ECV r maar Efcr niet aldosterone escape
geen





Omstandigheden

vaak 20 in Patna .




Effecten angiotensine 2
effecten aldosteron e
vr zetting aldosterone
• -
>




{


vasoconstr . arteriaen : eff > off → FF in



gÉ dus meer
gefilterd → Pd en Tr

Nasa recta)

reabsorptie
afvoer rosmolen
in

med bf
E. vertraging trager
.

.




TË voor reabs Nou in TALH
meer ureum
grotere gradiënt reabs.tn
→ →







TG NAU aanbod aan Mac Oi
fb GFR

: > .
-
> &
.




Ang 11 →

gevoeligheid î →
GFR Na b zelfde Na U aanbod



Rechtstreekse stimulatie Na + reabsorptu



hypertrofie Renaat tubulaeie cellen
⑤ dorst ✗
vr zetting ADH





combinatie water ✗ zout retentie




ij
ijij
ij
ij

, Sympatrisch 25
.

Constr .
lff > @ ff → FFP

renirie
vr zetting





.
+0 Na reabsorptie
-


Undressed situation : kleine rol sympaticus ,
bel .
rol b homeostase

ECF ( vb .

b hemorragische )
shock



Acties ADH
ECF Osmolaliteit
regeling





boven ADH
st ging drempelwaarde






.
Etc vd -
> ADH T vr zetting


effecten :



'

④ Nat reabsorptie

systemische vasoconstrictie
-




Acties atrial natrivtic peptide
EFCV & -7 ANP
vr zetting
Effecten hemootynamis.ch ( effecten dan
vooral
tegengestelde
FF &
de vorige 3)
BF 9
, , reabsorptie tv




ij
ijij
ij
ij

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