GNUR 294 EXAM IV Pharmacology of Coagulation Disorders:NEWEST-2022
1 view 0 purchase
Course
GNUR 294 (GNUR294)
Institution
Loyola University Chicago
GNUR 294 EXAM IV Pharmacology of Coagulation Disorders:NEWEST-2022GNUR 294 EXAM IV Pharmacology of Coagulation Disorders:NEWEST-2022GNUR 294 EXAM IV Pharmacology of Coagulation Disorders:NEWEST-2022GNUR 294 EXAM IV Pharmacology of Coagulation Disorders:NEWEST-2022
gnur 294 exam iv pharmacology of coagulation disorders
Written for
Loyola University Chicago
GNUR 294 (GNUR294)
All documents for this subject (66)
Seller
Follow
kuglin
Reviews received
Content preview
GNUR 294 EXAM IV
Pharmacology of Coagulation Disorders
Affects the clotting factors- anticoagulants
Prevent platelets aggregation, doesn’t change number of platelets- antiplatelet
Breaks down clot formation- thrombolytic drugs
Anticoagulants & Antiplatelets don’t break down clots
Drugs are geared towards one of these processes
A normal response
When you damage blood vessels, and there is injury the first thing to control hemodynamics
and homeostasis, the blood vessels spasm, and then builds a matrix that will seal the injured
vessels, and the clotting factors will come in and then from a thrombosis to clot, and stays
around to heal and then enzymes that will be secreted once healed to destroy and break
down clot
Anticoagulant/ Indirect Thrombin Inhibitor
o The most commonly used today
o Acute prevention of clot formation of enlargement by effecting those clotting factors
o Only given IV- prototype drug
o Some of the newer generations SQ
o Unfractionated – drugs molecules that differ in size from molecule to molecule.
Going to react differently from patient to patient. Needs to have labs drawn to see
that is it a therapeutic level for patient.
o Works fast and well, have to monitor blood work very frequently
o Because this considered a high risk medication there is an antagonist for heparin:
protamine sulfate. If you a patient that has gotten too much heparin
o Patient that is at risk for clotting-
o Think of Virchow’s triad- venous stasis, hypercoagulability, tissue injury
o Going to see venous stasis and tissue injury in hospitalized patients
o Also have patients who have are out of the hospital- people only on medications
(hormonal), someone on bed rest, flying in airplanes
o To prevent from a clot in occurring or to treat a patient of DVT forming will be
treated with heparin
o If it’s get dislodged, pulmonary embolism it will be preventing perfusion
o as it has been more developed some drugs that have evolved rom that
unfractionated strand to more a molecular weight. don’t really have to draw blood
o Draw aPPT- measured in seconds of time, the greater the number the longer it’s
going to take a lot someone’s blood
o 25-40 seconds: person not on heparin, we want to prolong that time. It will be 1 ½
to 2 times to clot from that patient’s baseline. Want it to prevent thrombin from
forming. aPPT: 60-80 seconds for a therapeutic level
o Physician will order heparin protocol, then have to recheck aPPT
o Thrombosis prevention in high risk- someone that predisposes them to more
clotting
o HIT- heparin induced thrombocytopenia, the antibodies are being formed towards
heparin but are affecting the platelets. The platelets will drop (patient will be at a
double risk for bleeding), due to a lot things are helping the cell walls, the patient
will be in a hypercoagulability state and increasing thrombosis size. No prevention.
Once they do have this they can never get heparin again
o HAS TO HAVE A CBC DONE EVERYDAY
o Patient factors that will have cause toxicity: metabolism problems, protein binding ,
medication error
o Severe hypertension- blood vessels might pop somewhere, cerebrovascular.
Heparin is sometimes used as a bridge for people who need anticoagulation long
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller kuglin. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $11.49. You're not tied to anything after your purchase.
