Summary First year medical school drugs with MOA and indications
8 views 0 purchase
Course
Medicine
Institution
Keele University (KU)
First year medical school drugs with MOA and indications from lectures and methods such as PBL
Can be used for medical school, biochemistry and biomedicine
Drug What it affects Mechanism of action
Lansoprazole – proton Amount of gastric acid levels + +
Blocks the proton pumps (H /K ATPase) on the
pump inhibitor in the stomach stomach parietal cells – lowering gastric acid
– used to treat GORD and levels in the stomach
stomach ulcers
Flucloxacillin Bacteria cell wall synthesis Inhibits the cross-linkage between linear
peptidoglycan polymer chains – it binds to
penicillin binding proteins inside the cell wall and
inhibits the last stage of bacteria wall synthesis –
cell lysis then occurs
Co – amoxiclav (clavulanic Bacteria cell wall synthesis -Clavulanic acid is a drug that stops bacteria from
acid and amoxicillin) inactivating amoxicillin.
-Amoxicillin binds to penicillin binding proteins in
the bacteria cell wall which inhibits the last stage
of bacteria cell wall synthesis – cell lysis then
occurs
Dexamethasone – Protein synthesis Crosses membranes and binds to cytoplasmic
glucocorticoid agonist glucocorticoid receptors which binds to DNA and
-Used in induction modifies transcription and hence protein
chemotherapy for acute synthesis which affects cell proliferation (also
lymphoid leukaemia (ALL) have anti-inflammatory traits)
Asparaginase Lack of asparagine Kills leukemic cells due to the depletion of plasma
-Used in induction asparagine as they cant produce it due to lack of
chemotherapy for acute asparagine synthetase. Normal cells are
lymphoid leukaemia (ALL) unaffected as they can synthesise asparagine.
Vincristine Mitosis – mitotic spindle Causes inhibition of microtubule formation in
-Used in induction mitotic spindle, resulting in an arrest of dividing
chemotherapy for acute cells at the metaphase stage
lymphoid leukaemia (ALL)
Mercaptopurine Purine nucleotide synthesis Inhibits purine nucleotide synthesis and therefore
-Used in maintenance alters the synthesis of DNA and RNA. It also
chemotherapy for ALL interferes with glycoprotein synthesis
Methotrexate Cell proliferation Works by inhibiting an enzyme called
-Used in maintenance dihydrofolate reductase which is important in
chemotherapy for ALL making some of the building blocks of DNA
production. By inhibiting this enzyme, it
interferes with the cells ability to repair and copy
itself (also has anti – inflammatory traits)
Adalimumab TNF receptors It’s a monoclonal antibody (IgG1) that neutralises
TNF-α by blocking its interactions with the cell
surface TNF receptors which then decreases
inflammation (by decreasing the vasodilation
which TNF-α causes)
Prednisolone Inflammation It has glucocorticoid properties – therefore
inhibits neutrophil apoptosis, NFxB and other pro
– inflammatory transcription factors and
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller danbastock01. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $7.17. You're not tied to anything after your purchase.
