Class notes
Bleeding Disorders
- Course
- Institution
Lecture notes on Bleeding Disorders
[Show more]
Seller
Follow
polinalobacheva
Reviews received
Content preview
Haemostasis and ThrombosisNormal Haemostasis
- The mechanism for dealing with bleeding and clotting is
called haemostasis
Abnormal bleeding
Bleeding disorders:
- Symptoms vary from easy bruising to spontaneous or
life-threatening haemorrhage
- Occur when components of haemostasis are deficient to an extent that you get excess
bleeding
Abnormal bleeding
1. Vascular disorders
2. Thrombocytopenia
3. Defective platelet function
4. Defective coagulation
- Vascular and platelet disorders associated with bleeding from mucous membranes and skin
- Coagulation disorders bleeding is often into the joints or soft tissue
Common Symptoms of Bleeding Disorders:
- Epistaxis
- Gingival bleeds
- Bruising
- Purpura or Petechiae
- Menorrhagia
- Joint bleeds
- Muscle bleeds
- Chronic anaemia
Platelet Disorders
, Bleeding Disorders associated with platelets - Platelet bleeding disorders can be:
1. Quantitative (reduced number) ,(<150 x 109/L)
a. thrombocytopenia
2. Qualitative (reduced function)
a. Acquired
b. Inherited (rare)
Thrombocytopenia
- Most common platelet disorder
- Most commonly acquired
- Reduced production (more severe) or increased destruction
- Characterised by:
- Spontaneous skin purpura
- Mucosal haemorrhage and prolonged bleeding after trauma
Acquired Platelet Dysfunction – Aspirin treatment
- Aspirin can be used in the prevention of atherothrombosis
- Aspirin permanently inactivates the cyclooxygenase (COX)
- COX-1 catalyses the conversion of arachidonic acid to
prostaglandin H2
- First committed step in the biosynthesis of thromboxane A2
- Thromboxane A2 triggers reactions that lead to platelet
activation and aggregation
- These effects last for the life of the anucleate platelet,
approximately 7 to 10 days.
Inherited Platelet Disorders
- Inherited platelet disorders are rare
- They can affect various aspects of platelet function including
platelet adhesion, secretion and aggregation
Historic Test – Bleeding time
- The bleeding time is operator dependent, poorly reproducible and neither objective or sensitive
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller polinalobacheva. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $13.05. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
67232 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now