100% satisfaction guarantee Immediately available after payment Both online and in PDF No strings attached
logo-home
Previously searched by you
Previously searched by you
logo
FA-MA106 Geneesmiddelontwerp Samenvatting leerstof $11.86   Add to cart
Quickly navigate to
Preview
  2.  
  3. Universiteit Utrecht (UU)
  4.  
  5. FA-MA106 Geneesmiddelontwerp (FAMA106)

Summary

FA-MA106 Geneesmiddelontwerp Samenvatting leerstof

1 review
 108 views  6 purchases
  • Course
  • FA-MA106 Geneesmiddelontwerp (FAMA106)
  • Institution
  • Universiteit Utrecht (UU)
  • Book
  • Recepteerkunde

In deze samenvatting van FA-MA106 Geneesmiddelontwerp vind je een uitgebreide uitwerking per behandelde thema (werk- en hoorcolleges). Ik heb de samenvatting opgedeeld in de volgende hoofdstukken: Geneesmiddelbereiding in de apotheek (kwaliteit eisen), Toedieningsvormen niet steriel (oraal, rectaa...

[Show more]

Preview 4 out of 50  pages

Document information

  • No
  • Alle hoofdstukken/ paragrafen die gelezen moesten worden in de cursus fa-ma106
  • February 14, 2022
  • 50
  • 2020/2021
  • Summary

Subjects

  • fa ma106
  • 106
  • geneesmiddel
  • ontwerp
  • geneesmiddelontwerp
  • design
  • samenstelling
  • hulpstoffen
  • kwaliteit
  • parenteraal
  • bereiding
  • productzorg

Connected book

book image

Book Title:

Author(s):

  • Edition:
  • ISBN:
  • Edition:

Written for

  • Universiteit Utrecht (UU)
  • Farmacie
  • FA-MA106 Geneesmiddelontwerp (FAMA106)
All documents for this subject (1)

1  review

review-writer-avatar

By: ireneluzac • 6 months ago

Seller

avatar-seller
Michelle1802

Reviews received

Content preview

FA-MA106
Geneesmiddelontwerp
Samenvatting

,Inhoud
Leerdoelen....................................................................................................................................................... 4
Algemene leerdoelen .................................................................................................................................. 4
Specifieke leerdoelen .................................................................................................................................. 4
Geneesmiddelbereiding in de apotheek ......................................................................................................... 5
Kwaliteitseisen ............................................................................................................................................ 5
Ontwerpkwaliteit ........................................................................................................................................ 5
Ketenkwaliteit ......................................................................................................................................... 6
Quality by design ..................................................................................................................................... 6
Drug substance/ farmacon Vs. Drug product/ geneesmiddel ..................................................................... 6
Effectiviteit .................................................................................................................................................. 6
Bereidingsverzoek ....................................................................................................................................... 7
Toedieningsvormen; niet steriel ..................................................................................................................... 8
Oraal ............................................................................................................................................................ 8
BCS-klasse ................................................................................................................................................ 8
Tabletten ............................................................................................................................................... 10
Capsules................................................................................................................................................. 11
Dranken ................................................................................................................................................. 13
Rectaal ....................................................................................................................................................... 14
Zetpillen................................................................................................................................................. 14
Klysma’s ................................................................................................................................................. 16
Dermaal ..................................................................................................................................................... 17
O/W crème ............................................................................................................................................ 17
W/O crème ............................................................................................................................................ 18
Zalf ......................................................................................................................................................... 18
Gel ......................................................................................................................................................... 19
Neus........................................................................................................................................................... 20
Toedieningsvormen; steriel........................................................................................................................... 21
Sterilisatie .................................................................................................................................................. 21
Sterilisatiekinetiek ................................................................................................................................. 21
Overkill-proces ...................................................................................................................................... 22
Bioburden-proces .................................................................................................................................. 22
Stoomsterilisatie.................................................................................................................................... 22
Heteluchtsterilisatie .............................................................................................................................. 22
Stralingssterilisatie ................................................................................................................................ 22
Gassterilisatie ........................................................................................................................................ 22
Membraanfilitratie ................................................................................................................................ 22
Parenteraal ................................................................................................................................................ 23
Injectievloeistoffen ontwerpen ............................................................................................................. 24

, Infusievloeistoffen ontwerpen .............................................................................................................. 24
Isotonie berekenen ............................................................................................................................... 25
Oculair (oogdruppels)................................................................................................................................ 28
Oordruppels .............................................................................................................................................. 29
Stabiliteit van geneesmiddelen ..................................................................................................................... 30
Fysische stabiliteit ..................................................................................................................................... 30
Amorf Vs. Kristallijn ............................................................................................................................... 30
Chemische stabiliteit ................................................................................................................................. 32
Hydrolyse............................................................................................................................................... 33
Oxidatie ................................................................................................................................................. 33
Fysisch-chemische analyse ........................................................................................................................ 34
Differential scanning calorimetry .......................................................................................................... 34
Thermo-gravimetrische analyse ............................................................................................................ 37
Microbiologische stabiliteit ....................................................................................................................... 38
Houdbaarheidsonderzoek ............................................................................................................................. 40
Stabiliteitseisen ......................................................................................................................................... 40
Gehalte .................................................................................................................................................. 40
Rekenvoorbeeld tetracyclinehydrochloridecrème 3% FNA ........................................................................ 41
Ontledingsproducten ............................................................................................................................ 42
Fysische- en microbiologische veranderingen ...................................................................................... 43
Stabiliteitsonderzoek................................................................................................................................. 43
Versneld Stabiliteitsonderzoek.............................................................................................................. 43
Lange termijn stabiliteitsonderzoek ...................................................................................................... 44
Tijdens gebruik stabiliteitsonderzoek ................................................................................................... 44
Doorlopend stabiliteitsonderzoek ......................................................................................................... 44
Reactiekinetiek .......................................................................................................................................... 44
Reactiesnelheid ..................................................................................................................................... 44
Temperatuur ......................................................................................................................................... 45
Rekenvoorbeeld reactiekinetiek ........................................................................................................... 45
Bijlagen .......................................................................................................................................................... 48
Bijlage I: Te kennen pKa’s .......................................................................................................................... 48
Bijlage II: Hulpstoffen overzicht ................................................................................................................ 49

, Leerdoelen

Algemene leerdoelen
Na afronding van de cursus is de student in staat:
Het ontwerp, de samenstelling en de productiemethode van geneesmiddelen te evalueren en te
beoordelen
Te beoordelen of een geneesmiddel aan alle criteria voldoet om het farmacotherapeutisch
gewenste effect te kunnen bewerkstelligen
Te reflecteren op zijn eigen professioneel gedrag

Specifieke leerdoelen
Na afronding van de cursus is de student in staat:
Op basis van probleemstellingen een uitvoerbaar werkplan op te stellen en daarbij de taken te
prioriteren, verdelen en (in teamverband) uit te voeren en te evalueren
Een geneesmiddel, farmaceutisch technologisch en biofarmaceutisch te karakteriseren
Kritische stappen in processen of systemen te herkennen en op basis daarvan protocollen op te
stellen; processen schriftelijk vast te leggen in protocollen
Tot het opstellen van keuringen op bereidingen en handelsproducten
Optimale condities voor transport en opslag van geneesmiddelen te bepalen en vast te leggen

The benefits of buying summaries with Stuvia:

Guaranteed quality through customer reviews

Guaranteed quality through customer reviews

Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.

Quick and easy check-out

Quick and easy check-out

You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.

Focus on what matters

Focus on what matters

Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!

Frequently asked questions

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

Satisfaction guarantee: how does it work?

Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.

Who am I buying these notes from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller Michelle1802. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy these notes for $11.86. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

66579 documents were sold in the last 30 days

Founded in 2010, the go-to place to buy study notes for 14 years now

Start selling
$11.86  6x  sold
  • (1)
  Add to cart