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Samenvatting immunologie 3
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ImmunologieAlgemene structuur van de immuunglobulinen
- Alle AL: opgebouwd uit 4 polypeptideketens
AL bestaan uit 4 polypeptiden:
- Ig hebben = basistructuur (IgG)
- H-keten (=zware)
- L-keten (=lichte)
- CDR’s of HV’s= complementaire determinerende
regio’s of Hypervariabele regio’s
- 1 zo een vierkant is een domein, bestaande uit
110 AZ
( Ig keten uit 1 oorspronkelijk gen ontstaan
is, dat zich meermaals gedupliceerd heeft)
- FC deel gaat vaak binden met macrofagen of
APC via eigen FC-receptor.
- Ag-bindingsplaats op beide armen
, De Z en L ketens hebben C en V delen:
- NH2-uiteinde v Z en L keten= V
- COOH-uiteinde hebben C AZ-sequentie binnen zelfde isotype
- Wrm HV op uiteinde?
- Is noodzakelijk omdat daar specifiek ons ag gaat binden aan AL. (=CDR regio:
complementaire determinerende regio’s). Beide op Z en L ketens, bepalen ag-
specificiteit.
- Secundaire ew-structuur v ketens= vouwblad
(karakteristieke 3dimensionele structuur= immuunglobuline-vouw)
Opvouwen v V, C domeinen.
Ew-keten meer opengetrokken.
-
Framework regios: ..
Verschillende enzymen splitsen de Al-molecule in verschillende stukken:
° Laat hoek tussen 2 Fab-delen
verschillen.
° AL kan 2 ag binden die op
verschillende afstand v elkaar liggen.
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