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Samenvatting immunologie 6

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Alles van hoofdstuk 6. cursus + ppt.

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  • February 15, 2022
  • 5
  • 2021/2022
  • Summary
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Immunologie
Inleiding




Legende

= beenmerg

“ de rest” = thymus




- Productie AL gebeurt door plasmacellen
- Plasmacellen komen voort uit B-lymfocyten
- “ 1 B-lymfocyt + nakomelingen produceert 1 antistof met 1 specificiteit”
- = beperking in expressie v zijn genoom. W aan lymfocyt opgelegd vr elk contact
met ag


Ontogenese v B-lymfocyt


- Voorlopers B / T-lymfocyt rijpen na geboorte  beenmerg
- Foetus  1e stamcellen in dooierzak, lever, milt
- B-lym die nog x ag ontmoet hebben = Virgo / naïeve lymfocyten
- V-lym  B-lym afhankelijke gebieden (= lymfatische klieren, milt)
- VB-lym wss kortlevend DUS nood aan ag stimulatie voor verdere differentiatie tot
rijpe langlevende circulerende B-lym
- Proliferatie, differentiatie  geheugen B-lym , AL secreterende plasmaC


Organisatie, codering v ALmolecule


- EXAMENVRAAG: “ v-deel opgebouwd uit 3 delen 
geef ze, pas
toe”

, - Differentiatie v stamcel  B-lym gepaard met TENMINSTE 2 genetische
herschikkingen die code v functionele ALmolecule samenstellen.
- 1e DNA herschikking  stelt code v Z-keten samen (V,D,J genen)
- Unieke combo vr V-deel van AL gevormd
- Code C-deel w x meteen gekozen
- Verandering in isotype = mogelijk, verandering specificiteit = x mogelijk
- 2e DNA herschikking  L-keten, herschikking V,J,C genen
- Multiple genen + somatische recombinatie geven tal van verschillende
mogelijkheden vr AL
- MAAR er kunnen tijdens ontwikkeling B-lym mutaties optreden
- Ieder individu kan met beperkt aantal genen vr AL een onbeperkt Samenvatting tekst
ALrepertorium genereren




AL diversiteit = gevolg v verschillende mechanismen




Herschikking genen die coderen
vr L-keten

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