Summary
Sumario Catálisis enzimática
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Mecanismo de catálisis de las enzimas.
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ENZIMAScat all SIS enzlmatlca
Veto cldadde react On
⑥ Mide Ias molecules de product 0 Obie ni das por Unidad de Tiempo 0 mole colas
de react IVO de grado das por Unidad de Tiempo .
" "
la vet 011 dad se mi de en Con di clones de Estado estacio nano
↳ cant 1 dad de SU Strato es
muy grande en compar act On con la cant lddd
eh ZI MATICA .
K,
Kz
E t S I ES → E t P
k l -
A [ D)
v =
At
Unidad enzl Mattia : cant 1 dad enzlmatlcaq.ve cat all 2- a la transform action
de 9µmol de SU Strato Dor MINUTO A 25°C .
VEIOCI dad 1h1 Ual (Vo ) : ES la Vel OCI dad en et period 0 In IUAI donde se produce
el product 0 rap 1dam ente → veiocl dad se reduce a meal da que se
consume el react IVO / Se pier de la actin dad en -21 Matica .
Curva de saturaclon
☒ MI de la retail On entre la velocldad initial y concentration de su Strato
se describe median Te la ECUACI On de Michaelis -
Menten
Vmax =
velocldad maxima de la enzima
Km =
LA [S ] a la Cudi la Vel 011 dad 1h1 CIAI e) la Milad
Vmax Is ] de la velocldad MAXIMA .
V= HAD la de la aflnldad entre la
Km + Is ] ↳
Ey et s SI hay
.
aflhldad , la km es bola , Pero si nay Poco
Aflnldad , la km es alia .
E
--.
d
É Vmax Tkm 4 [s ] para alcantar 42 Vmax → I aflnlddd
dkm d [ 5) Para Alcantar 112 Vmax → Tarini dad
km
concentration
su Strato
representation de line Weaver -
burk
☒ permit e definer dos para Metros Cuando no ten emos Curva aesaiuracloin
( Vmax y km )
☒ viiuzamos la equal 10h de la recta .
, a Km ^ 1-
T
=
Vmax
( Is] +
Vmax
PUNTOS de Corte =
l
r
y=
Vmax
✗ =
-
l '
/v
km
-
'
- imax
gradient e = -
,
,
)
1-
km
[s ]
kmax
- 1
km
Regula lion enzlmatlca
1. DISPONIDIU dad de en 2- Ima
→ cant load de en -21mA depend e de sus tazas de slntellsydegra Clacton
2. ACT I V1 dad de en 2- Ima
→ function am lento de una en -21mA puede verse afectadoporvarios
Fact ores
A. DISD 0h1 bill dad del su Strato / Coen 2-1 mas y o cofactor es
-
( OFA CT ores : feat ,
WZT
, Mg
2T
-
Coen Zlmas : NADT ,
NADP +
FADT
,
B. MOAIFI lactones covalent es
-
f- OIFOVIIACI On
'
-
Des FOI for 119110 n
C. ENZ IMAI Allosteric as
r.osr-orllacio.in
la , qui nasal son Ias de
•
encargadal FOI for all 2- ar .
• se na ce sobre ios rest duos de Ser, Thr 0 Tyr .
→ amino act dos mas pro pens 0s
• Reg v1 ere el Oso de ATP a FOIFO v11 arse
• Hale que una en 2- ima sea mas actlva .
Eg .
glvcogenofolforllasa
↳ En 2- Ima que degradaglucogeno .
↳ Esta act Iva Cuando se encuentro Fosforllada .
↳ Cuando nay insulin a pre sente ,
Voy a que rer que la glucogenofolforllasa
este INACTIVA
→ Cuando nay glucagon preterite , Voy a que rer que la giucogenorosforilasa
este aciiva .
Des FOI for 110110in
• las FOI Fatal as son las en cargo das de des Fos for all 2- ar .
• No require el Oso de ATP
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