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Samenvatting Alle antibiotica bacteriologie L. van Mellaert $5.89   Add to cart

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Samenvatting Alle antibiotica bacteriologie L. van Mellaert

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ik heb alle bacterien in tabelvorm samengevat tot 30 pagina's ik had zelf een 16/20 voor microbiologie

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  • February 17, 2022
  • 4
  • 2021/2022
  • Summary
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ANTIBIOTICA


INHIBITIE CELWANDSYNTHESE

-lactam AB VIER GROEPEN
allemaal lactam groep
1. penicillines
- nat rlijke penicillines
eng spectr m
lactamase ge oelig
- penicillinase resistant penicillins
eng spectr m
lactamase resistent
> o acillin / methicillin / MRSA
- aminopenicillines
breed spectr m
lactamase ge oelig
- carbo en reido penicillines
breed spectr m
cerbenicilline
2. cephalosporines


lactamase resistent
3. monobac ams
maar 1 ring
tegen G- aeroben
4. carbapenem
breed spectr m aak gebr ikt snelle resistentie
reactief tegen m ltiresistente pse domonas aer ginos m

WERKINGSMECHANISME
- lactamring met hoge reacti iteit t ssen C=O en N binding
- lactamring bindt aan penicillin binding pro ein PBP
= transpeptidase: erhindering crosslinking peptidogl caan ketens t rgordr k niet onder controle
cell se
= bactericide

RESISTENTIEMECHANISME
- lac amase: h drol se lactamring inactief AB
cla laan r = lactamase inhibitor: be at een ring aar lactamase op gaat binden competitie
met betalactamase in AB actief AB
- ij iging PBP meer transpeptidase prod ceren
- o erprod c ie PBP
- ij iging permeabili ei b i enmembraan AB niet meer tot peptidogl caanlaag

gl copeptide AB alleen tegen G+
ant is een groot molec l, niet doorheen G- laag

VANCOMYCINE
nat rlijk: door bact elf aangemaakt

TEICOPLANINE
s nthetisch

WERKINGSMECHANISME
- binding D-ala-D-ala an PG prec rsor erhindering transgl cos lase / transpeptidase geen
crosslinking PG cell se door aterinfl

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