Nursing Praxis & Professional Caring IV (LUSL2144)
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systemic lupus erythematosus
* chronic , multi system inflammatory disease
* associated with abnormalities of immune
system
* results from interactions
among genetic , hormonal , environmental , and immunological
* SLE affects 1 per 1000
people in Canada
* nine times more
likely in women than men
has effects joints renal system
* on : skin , , serous membranes , , hematological system ,
neurological system
etiology and pathophysiology >
etiology is unknown
most probable causes : autoimmune reactions directed against constituents of cell nucleus .
DNA
antibody B- T-cell
response related to and hyperactivity
clinical manifestations & complications
*
ranges from a relatively mild disorder to
rapidly progressive ,
affecting many body systems
* Most
commonly affects the skin and muscles , lining of lungs ,
heart ,
nervous tissue , and kidneys
immunological disorder → positive result of LE preparation ; anti -
DNA
antibody or
antibody to Sm false positive result of
nuclear antigen ; or
-
serological tests for syphilis
Malar rash
neurological disorders :
seizures or
psychosis
oral ulcers
photosensitivity
renal disorder :
persistent proteinuria or cellular casts in urine
serositis →
pleuritis or pericarditis
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