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Samenvatting Hoofdstuk 14
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Samenvatting van 3 pagina's voor het vak Farmacokinetiek & Toxicologie aan de Odisee
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IN VIVOAcute toxiciteitstesten: Meest gebruikte OECD 420 (fixed dose proces)
Eerst 1 proefdier (5mg/kg) (50mg/kg) hier toxiciteit deze dosis voor main studie, dier
dood dan 5mg/kg
Main studie bv startdosis 50mg/kg (meer dan 2 van de 5 proefdieren dood, procedure
opnieuw met lagere dosis)
Klasse met de geschatte LD 50
Subacute: meestal 5 x per week met 3 doseringen (herhaalde dosissen) MAX 1mnd
- Schade omonkeerbaar?
- Tolerantie?
- Opstapeling
- NOAL en LOAL bepalen
Subchroninsch: 10% levensduur van een duur (jonge ,groeispurten dieren) 1 groep met lage
dosis en groep met hoge dosis
- Latentieperiode
- Reversibel of niet
- Toxicokinetiek parameter
- Soort toxisch effect
Chronisch: knaagdieren en niet knaagdieren ook mannen ( 4 dosisgroepen : -controle , lage,
hoge en middel dosissen) 9-12 mnd (18mnd ratten en muizen)
- Laattijdige effecten opmerken
- NOAL en LOAL
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