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NR565 wk 7-8 Final Exam Study Guide BEST EXAM STUDY GUIDE LATEST GRADED A+
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NR565 wk 7-8 Final Exam Study Guide BEST EXAMSTUDY GUIDE LATEST GRADED A+
NR 565 Exam Final Study Guide
➢ Antacids: weak bases that react with hydrochloric acid to form salt & water.
o Used in the treatment of Hyperacidity, GERD, PUD, hyperphosphatemia, and calcium
deficiency
o Contain combinations of
▪ metallic cation (aluminum, calcium, magnesium, and sodium)
▪ and basic anion (hydroxide, bicarbonate, carbonate, citrate, and trisilicate)
➢ Pharmacodynamics, Pharmacokinetics, Pharmacotherapeutics
o Neutralize Gastric Acidity (causes ^pH of the stomach and duodenal bulb)
o Inhibit proteolytic activity of pepsin
o Increase lower esophageal sphincter tone
o Acid-neutralizing capacity ANC varies between products expressed in mEqs
o If ingested in a fasting state, antacids reduce acidity for approximately 20 to 40 minutes
o If taken 1 hr after a meal, acidity is reduced for 2 to 3 hrs
o A second dose taken after a meal maintains reduced acidity for more than 4 hrs after the
meal
o The action of antacids occurs locally in the GI tract with minimal absorption, minimal
metabolism
o ALL antacids are contraindicated in the presence of severe abdominal pain of
unknown cause, especially if accompanied by fever
-HIGH SODIUM content: pts w/ HTN, CHF, marked renal failure, or on low-sodium diets
need to use low sodium preparation
NR565 wk 7-8 Final Exam Study Guide BEST EXAM
STUDY GUIDE LATEST GRADED A+
,NR565 wk 7-8 Final Exam Study Guide BEST EXAM
STUDY GUIDE LATEST GRADED A+
-Concurrent administration with enteric-coated drugs, destroys the coating= alters
absorption, ^ the risk for adverse effects
-Administrations should be separated by at least 2 hours to decrease drug/drug interactions
1. Calcium based antacids: TUMS, Caltrate, Calcarb
• Prescribed to treat calcium deficient states, i.e. chronic renal failure, post-menopause,
and osteoporosis
• Used to bind phosphates in CRF
• Require Vitamin D for absorption from the GI tract
• Excreted mainly in feces, 20% in urine
• ADR: Contraindicated in the presence of hypercalcemia and renal calculi
• Can cause constipation- increase bulk, fluids and mobility, stool softener
• Administered 30min- 1hr on empty stomach or 3hr after meals
• Should not be administered with food containing large amounts of oxalic acid
(spinach, rhubarb), or phytic acid (bran, cereals), they decrease the
absorption of calcium
• Taking w/ foods containing phosphorus (milk, dairy) can lead to milk-alkali
syndrome (N/V, confusion, headache).
• Taking with acidic fruit juice improve absorption
2. Aluminum based: AlternaGEL, Amphojel, Mylanta
• Inhibit smooth muscle contraction and slow gastric emptying
• Used to bind phosphates in CRF
Aluminum removed by dialysis b/c it is bound to albumin & transferrin = do not cross dialysis
is not easily membrane
NR565 wk 7-8 Final Exam Study Guide BEST EXAM
STUDY GUIDE LATEST GRADED A+
,NR565 wk 7-8 Final Exam Study Guide BEST EXAM
STUDY GUIDE LATEST GRADED A+
• Not may result in dialysis osteomalacia
absorba o Aluminum deposits in bone and osteomalacia occurs
ble with • Elevated aluminum tissue levels contribute to the development of dialysis
routine encephalopathy
use • Used to treat hyperphosphatemia in pts w/ renal failure & phosphate renal stone
• Aluminu prevention
m • Can cause constipation- increase bulk, fluids and mobility, stool softener
concentr
ated in
the CNS
• Bind
with
phospha
te and
excreted
in feces
• Prolong
ed use
in
patients
with
renal
failure
NR565 wk 7-8 Final Exam Study Guide BEST EXAM
STUDY GUIDE LATEST GRADED A+
,NR565 wk 7-8 Final Exam Study Guide BEST EXAM
STUDY GUIDE LATEST GRADED A+
3. Magnesium based: Milk of mag, Maalox, Mylanta
• Can be used to treat magnesium deficiencies from malnutrition, alcoholism, or mag-
depleting drugs
• Contraindicated in patients with renal failure & used with caution in pts with renal
insufficiency
The • Not absorbable with routine use
malfuncti • Excreted in the urine
oning • Contraindicated in patients with renal failure, use with caution for patients
kidney with any degree of renal insufficiency
cannot o Malfunctioning kidney is unable to excrete magnesium and hypermagnesemia
excrete may result
magnesiu • Can cause diarrhea- increase fiber intake (Alkalosis may occur in renal impairment)
m=
Clinical Use and Dosing
hypermag
nesemia
NR565 wk 7-8 Final Exam Study Guide BEST EXAM
STUDY GUIDE LATEST GRADED A+
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