Class Notes Pulmonary Vasculitis and Respiratory Pharmacology
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Course
Medicine
Institution
Johns Hopkins University School Of Medicine
Book
Harrison\\\'s Principles of Internal Medicine, Twentieth Edition (Vol.1
This short summary includes main aspects of vasculitis related to Pulmonary system. Also as a bonus I have included some respiratory drugs that are used most in obstructive lung diseases: COPD, asthma.
Harrison's Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2) 20th Edition by J. Larry Jameson
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Content preview
■ GPA vs MP
Pulmonary Vasculitis Polyangii
ANCA; Mi
★ Vasculitis - inflammation of blood vessels; Vasculitides - its diseases
■ GPA - can
○ Primary:
imaging.
■ Large
■ EGPA - ch
■ Medium
ground-g
■ Small
■ DLCO - di
○ Secondary:
impractica
■ Infection
■ Drug reactions
■ Connective tissue disease
■ Malignancy
★ Classification of Vasculitides:
■ A - CT sho
consolida
pulmonar
alveolar se
○ Bronchoscopy wit
cytology - possibl
★ Diffuse Alveolar Hem
○ Life-threatening
○ Poor prognosis, in
○ Usually diffuse, ca
○ Classification:
■ Immune:
■ Congestiv
★ Pulmonary Vasculitis ■ Miscellan
○ Lung involvement in: drugs
■ Primary, idiopathic, small-vessel → Antineutrophil ■ Idiopathic
cytoplasmic antibody-associated vasculitides
● Wegener’s granulomatosis
● Microscopic polyangiitis
● Churg-Strauss syndrome → EGPA
■ Primary, idiopathic medium and large-vessel vasculitis →
primary immune complex-mediated vasculitis
■ Secondary vasculitis
○ Rare, incidence = 20-100/mln, prevalence = 150-450/mln
○ Small vessels affected - capillaries, also arterioles, venules
○ Small-vessel vasculitides:
■ Antineutrophil cytoplasmic antibody - ANCA associated
vasculitides - AAV
■ Immune-complex mediated vasculitides
○ Component of Systemic vasculitis
○ Vasculitides - difficult diagnosing
○ Signs/symptoms - overlap with infection, tumor, thromboembolic
disease, connective tissue diseases
○ Etiology of AAV - it is autoimmune so unknown
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