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BCM32 Samenvatting College 7 $3.24   Add to cart

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BCM32 Samenvatting College 7

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BCM32 Samenvatting College 7

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  • September 5, 2015
  • 4
  • 2013/2014
  • Summary
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BCM32 College 7
Cristy Verzijl
Actine en myosine

Signaaltransductie

Werking van spieren
Om spieren te laten werken is het nodig dat:
 Actine en Myosine een reversibele interactie
aangaan
 ATP gehydrolyseerd wordt
 Binding en Katalyse zijn functies die
toebehoren aan eiwitten



Motor eiwit: Myosine




Voornaamste eiwitten aanwezig in de spieren
Myosine(540 kDa), opgebouwd uit 6 subeenheden (2 zwareketensen 4 lichteketens)
Milde behandeling van
Myosine leidt tot splitsing
van het molecuul.




Myosine: S1
Aggregatie (samenvoegen) van Myosine:
vorming van een dik filament.




Voornaamste eiwitten aanwezig in de spieren



4

, Actine(42 kDa), opgebouwd uit monomere G-actine (42 kDa) die associëren tot F-actine.

F-actine vorming en afbraak




F-actine vormt met Tropomyosine en Troponine een dun filament
Tropomyosine verbindt ~7 actine eenheden met elkaar.




Interactie tussen Myosine en Skeletspier opbouw
Actine in de skeletspier




Samentrekking van de skeletspier




Ander eiwitten in het sarcomeer
Lengte van de sarcomeer wordt bepaald door het eiwit Titin




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