Biochemistry – C785
Unit 2 Quiz
1. Which level of protein structure is disrupted through the hydrolysis of peptide bonds?
a. Primary
2. A mutation in the beta-hemoglobin gene, which results in the replacement of the amino acid
glutamate in position 6 with the amino acid valine, leads to the ...
1. Which level of protein structure is disrupted through the hydrolysis of peptide bonds?
a. Primary
2. A mutation in the beta-hemoglobin gene, which results in the replacement of the amino acid
glutamate in position 6 with the amino acid valine, leads to the development of sickle cell
anemia. The structures of glutamate and valine are shown below.
If the beta hemoglobin gene in a patient with sickle-cell anemia were to be edited so that the
valine in position 6 was replaced with a different amino acid, which replacement for valine
would be expected to have the best clinical outcome, in theory, for the patient? (Assume the
valine can potentially be replaced with any amino acid other than glutamate.)
a. (amino acid structure 4)
3. Secondary, tertiary, and quaternary levels of protein structure can all be impacted by exposing a
protein to which treatment?
a. Placement of the protein in a solution with low pH.
4. An increase in beta-pleated sheet structure in some brain proteins can lead to an increase in
amyloid deposit formation, characteristic of some neurodegenerative diseases. What is the
primary biochemical process that follows the increase in beta-pleated sheet structure that leads
to the development of the amyloid deposits?
a. Aggregation of the proteins in the brain
5. Which level of protein structure is determined by the sequence of amino acids?
a. Primary structure
6. Which force is most influential in determining the secondary structure of a protein?
a. Hydrogen bonding
7. Which amino acid would most likely participate in hydrogen bonds?
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