1. Factors that affect the pharmacokinetics of lipophilic medications in older adults include:
a. greater adipose tissue ratio to body mass.
b. decreased total body water.
c. increased glomerular filtration rate.
d. increased creatinine clearance.
ANS: A
Rationale
Older adults have a higher ratio of adipose (fat) tissue where lipophilic (fat-soluble)
medications can be stored thus resulting in a potential for an accumulation of the medication
and potentially fatal overdoses. Older adults have a decrease in lean body mass and an
increase in fat. An increased body mass would not affect lipophilic medication absorption.
Older adults have a decreased glomerular filtration rate, which begins to decline as early as
age 25. Older adults have a decrease in overall kidney function.
DIF: Cognitive Level: Remembering REF: p. 103
TOP: Integrated Process: Teaching/Learning
MSC: Client Needs: Health Promotion and Maintenance
2. Which pharmacokinetic/pharmacodynamic parameter does the aging process least affect?
a. Absorption
b. Distribution
c. Metabolism
d. Excretion
ANS: A
Rationale
There is no conclusive evidence that the absorptive process is changed appreciably in older
adults. Distribution, metabolism, and excretion are all affected significantly by aging.
DIF: Cognitive Level: Remembering REF: p. 107
TOP: Integrated Process: Teaching/Learning
MSC: Client Needs: Health Promotion and Maintenance
3. What factor is an important contribution to polypharmacy in older adults?
T his study source was downloaded by 100000843952123 from CourseHero.com on 04 -14-2022 18:24:05 GMT -05:00
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, a. Inadequate communication among medical care providers
b. Implementation of Medicare Part D prescription drug benefit
c. Use of generic medications
d. Increasing popularity of dietary and herbal supplements
ANS: A
T his study source was downloaded by 100000843952123 from CourseHero.com on 04 -14-2022 18:24:05 GMT -05:00
https://www.coursehero.com/file/45564469/c9rtf/
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