Dit bestand is een samenvatting. Echter is het niet erg mooi afgewerkt en beschouw ik het daardoor als class notes.
Toch staat de informatie er wel. Met behulp van deze samenvatting had ik een 8.5 gescoord.
Hoorcollege 8: The innate immune system
1st line of defense: physical barriers
• Mechanical barriers: skin, hair, nails
• Chemical barriers: low pH, ucus, enzymes
• Microbiological barriers: normal flora of the skin and in the intestine
2nd line of defense: innate immune system
• Phagocytosis Complement
• Interferon
• Infammation
• Fever
3rd line of defense: adaptive immune system
• Lymphocytes Antibodies
Recognation mechanisms of innate immunity Recognation mechanisms of adaptve immunity
Rapid response (hours) Slow response (days to weeks)
Fixed Variable
Limited numer of specificities Numerous highly selective specificities
Constant during response Improve during respons macrophages/neutrophils/NK cells Lymphocytes (T and
B)
Neutrophilen zijn vooral in ons bloed te vinden. 70% van alle leukocyten in het bloed behoren tot de innate immuun
systeem.
Kenmerken van de innate immuun systeem:
- Aanwezig bij de geboorte
- Werken snel
- Aspecifiek
- Geen geheugen
- Snelle verwijdering van het pathogeen
Deelnemers van de innate immuun systeem:
- Complement
- Neutrophils
- Macrofagen
- Dendritische cellen
- NK cellen
Functies van de innate immuun systeem:
- Phagocytosis
- Lysis of infected cells
- Production of inflammatory cytokines
- Production of chemokines to attract other immune cells
Pathogenen kunnen op verschillende locaties in het lichaam zitten. Voor
elke locatie is een verschillende reactie vereist.
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