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Samenvatting Oplossingen hoofstuk 7

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Oplossingen hoofstuk 7

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  • May 10, 2022
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Klinische chemie en hematologie voor analisten, deel 2, ISBN: 978 94 91764 110

Tweede herziene druk, © 2015, Syntax Media, Utrecht

www.syntaxmedia.nl



Uitwerkingen

Hoofdstuk 7


Antwoord 1

pH = 6,1 + log (7,0/(0,23 x 4,0) = 6,98. De pH is zeer sterk verlaagd; je moet nagaan of de
meting goed is verlopen.



Antwoord 2

Bicarbonaatconcentratie wordt niet gemeten, maar berekend uit de pH en pCO2 met behulp
van de Henderson-Hasselbalch-formule.



Antwoord 3a

Een metabole acidose ten gevolge van ophoping van zure ketonen die ontstaan bij de
verbranding van vetten. Door gebrek aan insuline stapt het lichaam over van
glucoseverbranding op vetverbranding. De ophoping van ketonen veroorzaakt een acidose,
en wordt ook wel keto-acidose genoemd.

Antwoord 3b

Beide zijn verlaagd.

Antwoord 3c

De longen zullen meer CO2 gaan uitademen (hyperventilatie) om zuur proberen kwijt te
raken. De pCO2 zal hierdoor dalen, waardoor de pH stijgt (compenseert). Er is dan sprake
van een metabole acidose die respiratoir gecompenseerd is.

Antwoord 3d

Naast ketonen is ophoping van lactaat een veelvoorkomende oorzaak van een metabole
acidose.

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