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Midterm Exam (Latest 2022): NR 565 / NR565 Advanced Pharmacology Midterm Exam Review|Rated A| Chamberlain College $12.49
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Midterm Exam (Latest 2022): NR 565 / NR565 Advanced Pharmacology Midterm Exam Review|Rated A| Chamberlain College

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NR 565 / NR565 Advanced Pharmacology Midterm Exam Review| Chamberlain College 1. Typical Antipsychotics - A class of older drugs to treat schizophrenia and related psychotic disorders primarily by reducing excess levels of dopamine in the brain - do not give to elderly, neuroleptic mali...

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  • May 27, 2022
  • 16
  • 2021/2022
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NR 565 / NR565 Advanced Pharmacology Midterm Exam
Review| Chamberlain College

1. Typical Antipsychotics

- A class of older drugs to treat schizophrenia and related psychotic disorders
primarily by reducing excess levels of dopamine in the brain

- do not give to elderly, neuroleptic malignang syndrome with high fever,
increased HR, diaphoresis, rigidity, coma, many EPS

- do not stop suddenly, do not drive with it, wear sunscreen, monitor gait

- chlorpromazine, thioridazine, fluphenazine, fluphenazine decanoate,
perphenazine, trifluoperazine, haloperidol, loxapine



2. atypical antipsychotics

- Antipsychotics that do not have significant side effects common to older
antipsychotics

- agranulocytosis is deadly s/e, has EPS but less than others, no alcohol

- Olanzapine (obesity), Clozapine (agranulocytosis), Respiradone (increase
prolactin)



3. Dopaminergics

- Treat parkinsons by enhancing dopamine

- do not give to schizophrenic patients

- levodopa (sinemet)

, - stand up slowly, inhibited by protein



4. Benzodiazepines

- The most common group of antianxiety drugs, increases GABA and
decreases neuronal excitation

- do not mix with cns depressive agents

- Valium, xanax, ativan



5. Serotonergic anxiolytics

- Enhances serotonin to relieve anxiety

- No CNS depression, no anticonvulsant properties, very mild SE

- Buspirone, ipsapirone, gepirone



6. Barbiturates

- drugs that depress the activity of the central nervous system, reducing
anxiety but impairing memory and judgment, treat epilepsy, seizures,
insomnia

- do not suddenly discontinue, CNS depression does occur, decreases many
other medications such as beta blockers

- pentobarbital, -barbital etc



7. sedative-hypnotics

- Drugs that can act in the body either as sedatives or as hypnotics, depress the
CNS

, 8. Benzodiazepine hypnotics

- Diazepam, Midazolam, Zolazepam
- Potentiates the inhibitory action of GABA. Activation of the receptor causes
an influx of Cl- ion movement into the neuron and hyperpolarization and
inhibition of membrane depolarization

- Addicting



9. Nonbenzodiazepine hypnotics

- Zolpidem, Zaleplon, exZopiclone. "ALL ZZZs put you to sleep."

- MOA: act via BZ1 subtype of GABA receptor. Effects reversed by
flumazemnil

- Use: insomnia

- SE: ataxia, headaches, confusion. Short duration. Decreased depdence risnk
like bneozs and only modest daf-after pscyhomoter depression



10. mood stabilizers

- drugs used to control mood swings in patients with bipolar mood disorders


11. Lithium

- Inhibits IP3 second messenger cascade, mood stabilizer for bipolar



- therapeutic range 0.6 to 1.5

- causes congenital malformations

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