Summary
Samenvatting herkennende structuren Organische Chemie II (K03B0B)
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samenvatting van de structuren die herkend dienen te worden
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Dopamine- neurotransmittor voor bewegingscontrole en evenwicht
- tekort bij verlies van neuronale cellen wordt gecompenseerd met L-DOPA (gaat
doorheen BBB). Activiteitsverlies door het monoamine oxidase wordt tegengegaan
door inhibitoren.
SAM
- ( S-Adenosyl methionine )
- in vivo een biologisch methylerend agens
- Noradrenaline als Nu op koolstof van methyl
- S = LG
- vorming van epinephrine (= adrenaline ).
- SN2
Methyltetrahydrofolaat
- methylerend agens.
- Nu op methyl
- Amine = LG
- thymine uit Uracil.
- SN2
, HGPRTase
- Hypoxanthine Guanine Phosphoribosyl Transferase
- SN2-type enzymatische reactie.
- als Nu op de koolstof, gebonden aan 2P
- pyrofosfaat = LG
- inosine monofosfaat
- deficientie geeft mentale retardatie.
Glutathione
- nucleofiel dat ons beschermt tegen elektrofielen die reageren met
proteïnen en DNA.
- S- = LG
- O- = carboxylaat
- Glu-Cys-Gly
- SN2 product is erg polair en makkelijk te excreteren.
Alkylerende agentia :
- Antikanker producten
- adderen alkyl groepen op DNA via SN2.
- Cl- en CH3SO3- = LG.
- 2 leaving groepen resulteert in DNA
crosslinking, een toxisch proces.
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