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Samenvatting theorie van de oefeningen deel 1 Algemene Farmacologie En Farmacokinetiek (K02B9A)
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samenvatting van oefeningen
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5. Kwantitatieve aspecten van farmacokinetiekInvasief: bloed, cerebrospinaal vocht, synoviaal vocht, weefsel biopsie
Niet invasief: excreta (stoelgang en urine), uitgeademde lucht, speeksel (=metabolieten)
Anticoagulans = bloedstolling tegengaan, in
vloeibare toestand houden
Serum = bloedstollingsfactoren aanwezig
Anticoagulantia
- Vooraf aanbrengen in proefbuizen
- Heparine (Na+ of Li+ zout)
- Ca2+ chelatie (= complexeren)
o K2EDTA
o Citraat, oxalaat
- Fluoride
Heparine:
- Trombine voor normale bloedstolling
- Trombone complex met anti-trombine dan wordt het
gestabiliseerd door Heparine en gaat het de bloedstolling
tegengaan.
Plasma: anticoagulans
Buffy coat: WBC en BP
Plasma makkelijker dan bloed
Plasma concentratie > bloed concentratie
Cp
Clbh = CLh x Clbh = hepatische bloed klaring = hoe graag het naar plasma wilt
Cb
Clbh
E= E = extractieratio
Qh
B/P = bloed/plasma
Kleine klaring graag naar BC kleine extractieratio
Grote klaring graag naar plasma grote extractieratio
, GM concentratie tussen MEC en MTC = therapeutisch venster therapie = actiemechanisme
Vd = distributie volume
Cl = klaring
k = eliminatie half waarde tijd
t1/2 = eliminatie half leven
INTRAVENEUZE TOEDIENING
Eén compartiment model
E = eliminatie
k = eliminatieconstante
D = dosis /Ab = hoeveelheid GM
Lineair (log Cp ipv tijd): k . Vd = Cl
D
Cp0 = (mg/L)
Vd
ln (2)
t1/2 =
k
Cp = Cp0 . e−kt
Therapeutische range tussen 0.3 en 5 mg/L
Hoe lang is therapeutisch venster: Cp = 0.”
Welke dosis nodig voor Cp0 = 5 mg/L
Intercept y = ln Cp0 Vd = D/ Cp0
Helling = -k Cl = k.Vd
D
Cl =
AUC
Twee compartiment model
R = herdistributie verplaatsing
D = distributie
GM verdeelt zich trager naar weefsels van perifeer
compartiment
A1 = D = drijvende kracht voor de snelheid
Drie compartiment model
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