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Samenvatting GUT_BRAIN studium generale

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GUT_BRAIN studium generale

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  • May 29, 2022
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  • 2021/2022
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GUT-BRAIN
Lezing: peter verstraelen

Onderzoeksvraag: een rol voor de darm-brein verbinding in neurodegeneratieve
aandoeningen?

- Neurodegeneratieve aandoeningen

Neurodegeneratie = aandoening waarbij neuronaalweefsel progressief zal afsterven
met neurologische dysfunctie tot gevolg
Bv ziekte van alzheimer, parkinson -> dag/nacht omkeren, geheugenverlies, …

Vaak begint jaren voor de diagnose symptomen -> hersenen geven functie door aan
gewone neuronen na een bepaalde tijd = niet meer mogelijk en zal de ziekte zich
uiten

 Vaak geassocieerd met ophopingen van toxische eiwit aggregaten in de hersenen

 bevatten -> imuuncomponent (imuun systeem zal reageren op ophoping)
concept van inflamaging (inflamatie + verouderen) -> bij veroudering lichte
chronische activatie van het imuun systeem, en zal dan ook bijdragen aan
veroudering

 multifactoriële oorzaak – samenspel van risicofactoren (genetisch of omgeving) ->
moeilijk om oorzaak te vinden

 Vaak nog symptomatisch en inadequaat behandeld omdat we de degeneratie nog
niet kunnen aanpakken (slechts tijdelijke hulp)


Ziekte van parkinson




- Opstapeling van -synucleine aggregaten (= lewy-bodies)

- Activatie microglia (neuroinflammatie)

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