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PACOP VIOLET MODULE 4. BIOPHARMACEUTICS AND PHARMACOKINETICS
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  • Module
  • PACOP VIOLET MODULE 4
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  • Our Lady Of Fatima University

PACOP VIOLET MODULE 4. BIOPHARMACEUTICS AND PHARMACOKINETICS.1. It is the ability of a drug to exist in two or more crystalline form: A. Chirality B. Polymorphism C. Stereoisomerism D. A and C E. None of these 2. Arrange the following dosage forms from highest to lowest dissolution rate: I...

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  • May 31, 2022
  • 122
  • 2021/2022
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  • biopharmaceutics and pharmacokinetics
  • pacop violet module 4 biopharmaceutics and pharmacokinetics
  • it is the ability of a drug to exist in two or more crystalline form
  • which of the following is not tr

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  • Our Lady Of Fatima University
  • PACOP VIOLET MODULE 4
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Module 4 New PACOP D. I, II and III
BIOPHARMACEUTICS AND E. None of these
PHARMACOKINETICS
5. Which of the following is not true regarding
1. It is the ability of a drug to exist in two or more the purpose of tablet coating?
crystalline form: A. Improves palatability
A. Chirality B. Improve aesthetic value of tablet
B. Polymorphism C. Improve stability
C. Stereoisomerism D. Improve in-vivo degradation
D. A and C E. None of these
E. None of these
6. A surface active agent that facilitates the
2. Arrange the following dosage forms from absorption of lipophilic drug or water insoluble
highest to lowest dissolution rate: drugs.
I. Solution A. Bile
II. Capsule B. Albumin
III. Suspension C. Rennin
IV. Tablet D. Gastric acid
E. None of these
A. I, II, III, IV
B. I, III, II, IV 7. Phase 2 metabolism that protects the body
C. IV, III, II, I against chemically reactive metabolites
D. IV, II, III, I A. Sulfate conjugation
E. None of these B. Glutathione conjugation
C. Methylation
3. All of the following statements are true D. Acetylation
regarding particle size of a drug, EXCEPT: E. Glycine conjugation
A. Reducing the particle size can decrease the
surface are of the molecule exposed to the 8. All of the following listed below are
solvent procecesses of drug excretion, EXCEPT
B. Reduction of particle size can be achieved by A. Glomerular filtration
micronisation using jet mill, spray drying and air B. Active secretion
attrition methods C. Tubular secretion
C. The dissolution of some drugs available in the D. Tubular reabsorption
market has been improved by reducing the E. None of these
particle size
D. Reducing the particle size of a drug may 9. It is the functional unit of the kidney
increase drug absorption A. Glomerulus
E. None of these B. Loop of henle
C. Nephron
4. Which of the following may increase drug D. Collecting tubule
dissolution rate? E. None of these
I. Too much binder
II. Insoluble diluents 10. Creatinine clearance of a patient with kidney
III. High amount of lubricants failure
A.60-89 mL
A. I only B. 30-59 mL
B. I and II C.15-29 mL
C. II and III D. <15 mL

,E. None of these 15. Volume of serum or blood completely
cleared of the drug per unit time.
11. Which of the following drugs listed below will A. Volume of distribution
increase its clearance at alkaline urine? B. Clearance
I. Amphetamine C. Elimination
II. Imipramine D. Plasma concentration
III. Barbiturates E. None of these
IV. Salicylic acid
16. Hypothetical volume that relates drug serum
A. I and II concentrations to the amount of drug in the
B. II and III body.
C. III and IV A. Volume of distribution
D. All of these B. Clearance
E. None of these C. Drug elimination
D. Plasma concentration
12. Which of the following correctly describes E. None of these
ion trapping?
A. Changing the pH of urine used to facilitate the 17. All of the following factors affects the volume
elimination of drug that proved to be toxic to a of distribution of drug, EXCEPT:
patient or has been taken in overdosed amount A. Volume of blood
B. Administration of acidic drug to neutralize an B. Size of venous organs and tissues in the
alkaline poison in the stomach body
C. Alkalanizing the urine to facilitate excretion of C. Protein binding
weakly basic drugs D. Physicochemical properties of drug
D. A and C E. None of these
E. None of these
18. The fraction of the administered dose that is
13. Discipline that applies pharmacokinetic delivered to the systemic circulation is known as
concepts and principles in humans in order to the:
design individualized dosage, regimens that A. Loading dose
optimize the therapeutic response of a B.Maintenance dose
medication while minimizing the chance of an C. Bioavailability
adverse drug reaction. D. Active dose
A. Clinical toxicology E. None of these
B. Clinical pharmacy
C. Clinical pharmacokinetics 19. Below is an example of:
D. Pharmacotherapeutics
E. None of these

14. Chemical coversion of the drug molecule,
usually by an enzymatically mediated reaction,
into another chemical entity referred to as a
metabolite.
A. Absorption A. Dose-response curve
B. Distribution B. Plasma-level time curve
C. Metabolism C. Quantal-dose response curve
D. Excretion D. A and B
E. None of these E. None of these

,20. After the first dose of gentamicin is given to allows the transfer of the free drug molecule but
a patient with renal failure, the following serum not the drug bound to protein.
concentrations are obtained: A. Ultrafiltration
B. Equilibrium dialysis
C. Hemodialysis
Time after drug Concentration D. A and B
administration (h) (mcg/mL) E. None of these
1 7.7
e 5.6
24. Which of the following statements are true
48 4.0
regarding volume of distribution (Vd)?
A. Relates the amount of absorbed drug with the
A. 30 hours and 0.0123/hr amount of eliminated drug
B. 45 hours and 0.0146/hr B. Total volume of drug absorbed
C. 55 hours and 0.0129/hr C. Drugs that are highly distributed into the
D. 50 hours and 0.0139/hr tissues have low Vd
E. None of these D. Drugs that are highly bound to plasma
proteins have low Vd
21. All of the following are true regarding the E. All of these
rate of drug distribution, EXCEPT:
A. The rate of drug distribution wil be faster in 25. For nos. 25-29:
highly prefuse tissues A single IV bolus of drug was administered to a
B. The blood brain barrier (BBB) prevents the patient and the amount of drug in the body was
distribution of many polar compounds in the determined at different time points after drug
blood to the brain tissues administration:
C. Only the lipophilic compounds can distribute
across BBB by passive diffusion
D. The equilibrium between the drug in highly Time (h) Amount (mg)
perfused tissues is achieved slower than the 0.5 396
equilibrium between the drug in blood and the 1 315
poorly perfused tissues 2 198
E. None of these 4 79
8 12.4
12 1.96
22. Which of the following factors affect drug
distribution?
What is the order of the elimination process of
I. Blood perfusion
this drug?
II. Tissue composition
A. Zero order kinetics
III. Plasma protein binding
B. First order kinetics
IV. Physicochemical properties of drug
C. Second order kinetics
D. A or B
A. I only
E. None of these
B. I and II
C. II and III
26. What is the rate constant for elimination
D. I, II, III and IV
process?
E. None of these
A. 0.5712/hr
B. 0.3789/hr
23. Technique in the determination of drug
C. 0.6234/hr
plasma protein binding that utilize a special
D. 0.4617/hr
dialysis chamber that is separated into two
E. 0.2341/hr
halves by a semipermeable membrane that

, C. Quinidine
27. What is the dose of drug administered to this D. A and B
patient? E. B and C
A. 500 mg
B. 300 mg 32. Elimination of a drug refers to:
C. 200 mg I. Excretion of uncharged drug in the urine
D. 100 mg II. Renal excretion of drug
E. 700 mg III. Uptake of drug from the blood into the liver
IV. Metabolism of drug in the liver
28. Calculate the amount of drug in the body V. Distribution of drug into fat
10h after administraton
A. 5.32 mg A. I and II
B. 3.45 mg B. II and III
C. 4.94 mg C. II and IV
D. 3.22 mg D. III and V
E. 6.55 mg E. None of these

29. What is the half-life of the drug immediately 33. The loading dose of a drug is determined by:
after drug administration? I. Drug clearance
A. 3 hrs II. Elimination rate
B. 5 hrs III. Target plasma drug concentration
C. 2.5 hrs IV. Volume of distribution
D. 1.5 hrs V. Duration of drug effect
E. 3.5 hrs
A. I and II
30. For nos. 30-31 B. II and III
C. III and IV
The following are the pharmacokinetic D. IV and V
parameters for a group of drugs E. All of the above

34. Half-life:
Drug Vd (L/Kg) Elimination I. Increases as the clearance increases
rate constant II. Decreases as the volume of distribution
(h-1)
increases
Theophylline 0.45 0.11
Ampicillin 0.3 0.6 III. Decreases as clearance increases
Quinidine 3 0.08 IV. Increases as volume of distribution increases
Gentamicin 2 0.08 V. Increases as the elimination rate increases
Digoxin 20 0.01
A. I and II
Which drug has the highest ClT? B. II and III
A. Theophylline C. III and IV
B. Ampicillin D. IV and V
C. Quinidine E. None of these
D. Gentamicin
E. Digoxin 35. After a single dose of a drug which has a
half-life of 12 hours, what percentage of the
31. Which drug has the lowest ClT? dose is still in body after 1 day?
A. Theophylline A. 87.5%
B. Ampicillin B. 75%

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