An overview of the lecture on important attributes of drugs including efficacy, potency and safety. Also covered is the action of agonists as drugs, selectivity and specificity of agonists and the idea of therapeutic index.
PHARMACOLOGY
What is a Drug?
What is a drug?
- A substance which when taken has a physiological or psychological effect on
the body and its functions
- An active substance with a direct effect in the diagnosis, cure, mitigation,
treatment or prevention of disease
What is a placebo?
- A substance with no therapeutic effect
- An inactive substance with no physiological effect, often used as controls
when testing new drugs
Important attributes of drugs
Efficacy – How big is the maximum response?
Potency – How big a dose is needed to produce the desired response?
Variability – What proportion of patients will have the desired response?
Selectivity – How effectively does the drug act on its molecular target and not on
other molecules?
Safety – What proportion of patients will have unwanted effects (U/E)?
Bioavailability – how much of an administered drug dose reaches its target?
Cost – how much does a course of drug therapy cost?
Command and control molecules (Lock and key)
Tiny amounts of drugs passing through the body can have such big effects because even
though they are mostly chemically inert, they bind transiently to command-and-control
molecules in the body because their molecular structures are complementary thereby
causing an effect.
Examples of command and control molecules:
Membrane receptors (for neurotransmitters, hormones etc)
Ion channels (that transmit nerve impulses)
Enzymes (that produce or degrade messenger molecules)
Nuclear receptors (that control gene activation)
Agonists
An agonist may be an endogenous substance or a drug that binds reversibly to a receptor
- Insulin acting on insulin receptors
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller sk11g12. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $3.88. You're not tied to anything after your purchase.