Summary Key aspects of the hepatitis D virus's microbiology
3 views 0 purchase
Course
Introduction of Microbiology
Institution
The University Of Liverpool (UoL)
The morphology and structural characteristics of the hepatitis delta virus are clearly shown in this lesson plan. It also provided a thorough demonstration of the pathogencity, clinical characteristics, and disease prevention.
Introduction
Hepatitis delta virus or HDV was discovered in patients with a more severe
form of human hepatitis B virus (HBV) infection
HDV is often called a virus but strictly speaking, it does not satisfy the
definition of a virus and should be called subviral.
Morphology and structural features
HDV is a small, spherical RNA virus measuring 36 nm in diameter with an
inner nucleocapsid that consists of a short single-stranded, circular RNA
and approximately molecules of hepatitis D antigen (HDAg)
The outer coat of the HDV virion consists of components taken from HBV,
thus mandating a coinfection process with HBV
The envelope of HDV particles contains the HDV surface antigen
(HBsAg), which includes the small, medium, and large HbsAg
Characteristics and life cycle
This pathogen replicates in the liver and frequently causes fulminant
hepatitis
Hepatitis delta virus has also been associated with the development of liver
cancer.
The process of their invasion and proliferation takes place through
the following steps
First, the HDV virion binds to the human hepatocyte through an interaction
between the large HBsAg and the host receptor
Entry, the HDV genome is translocated to the nucleus via the HDAg
Upon arriving in the nucleus, HDV commandeers host RNA polymerase II,
a DNA-directed RNA polymerase, for transcription of HDV RNA.
Replication of the HDV occurs through a rolling-circle mechanism
The next step is the synthesis of multimeric linear transcripts from the
circular genomic template
-
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller malshaninm. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $13.37. You're not tied to anything after your purchase.
