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Summary Key aspects of the hepatitis D virus's microbiology $13.28
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Summary Key aspects of the hepatitis D virus's microbiology

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The morphology and structural characteristics of the hepatitis delta virus are clearly shown in this lesson plan. It also provided a thorough demonstration of the pathogencity, clinical characteristics, and disease prevention.

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  • July 4, 2022
  • 3
  • 2021/2022
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Hepatitis Delta Virus

Introduction
 Hepatitis delta virus or HDV was discovered in patients with a more severe
form of human hepatitis B virus (HBV) infection
 HDV is often called a virus but strictly speaking, it does not satisfy the
definition of a virus and should be called subviral.

Morphology and structural features
 HDV is a small, spherical RNA virus measuring 36 nm in diameter with an
inner nucleocapsid that consists of a short single-stranded, circular RNA
and approximately molecules of hepatitis D antigen (HDAg)
 The outer coat of the HDV virion consists of components taken from HBV,
thus mandating a coinfection process with HBV
 The envelope of HDV particles contains the HDV surface antigen
(HBsAg), which includes the small, medium, and large HbsAg
Characteristics and life cycle
 This pathogen replicates in the liver and frequently causes fulminant
hepatitis
 Hepatitis delta virus has also been associated with the development of liver
cancer.


The process of their invasion and proliferation takes place through
the following steps

 First, the HDV virion binds to the human hepatocyte through an interaction
between the large HBsAg and the host receptor
 Entry, the HDV genome is translocated to the nucleus via the HDAg
 Upon arriving in the nucleus, HDV commandeers host RNA polymerase II,
a DNA-directed RNA polymerase, for transcription of HDV RNA.
Replication of the HDV occurs through a rolling-circle mechanism
 The next step is the synthesis of multimeric linear transcripts from the
circular genomic template
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