Lecture notes Cells and Immunity Immune Responses to Infection (BI2BC45)
1 view 0 purchase
Course
Cells and Immunity (BI2BC45)
Institution
University Of Reading (UoR)
The final lecture in a series for the module Cells and Immunity. This lecture covers infection in the body including salmonella, helminth, influenza and more. A great way to start your understanding of the module or to miss a lecture or two.
Lecture:
Main points of infection
o Point of entry
o Systemic vs localized infection
o Role of the spleen (blood filtration)
Large organ found on left
Not connected to lymphatic system
o Intracellular vs extracellular?
Cellular or humoral immunity?
Extracellular
Phagocytosis in interstitial space, blood and lymph
Antimicrobial peptides and IgA antibodies on epithelial
o T cell response (recognition and effector)
Recognize, innate immune response, present MHC, activate T cell and B cells
then effect w/ antibodies, granulocytes and cytotoxic killers
Non-self-recognition
o TLR-2 recognition Peptidoglycan only found in cell walls of bacteria recognition
o TLR-4/CD14 recog gram – bacteria LRS
o Scavenger receptor looks for sialic acid in bacteria/yeast
Effector T cells phenotype
o Inflammatory T helper 1 cell = IL-2 (inflammation)
B cells helpers ()
o T reg (anti-inflammatory)
o Signals then lead to different subtypes of B cells to produce different antibodies
(prolif/differentiation cytokines)
Diff isotypes (eg IgG vs IgE) vary in purpose eg neutralization vs sensitization
Fc = constant factor on antibody and Fab = antibody binding factor
Influenza virus
o Infection through air droplets and infect epithelial cells in lungs
o Type I IFN response initiated within 24h
IFN alpha and IFN beta synth and secreted by macrophages/dendritic cells
induced by noticing ds RNA
Increase MHC class 1 presentation in all cells, activate NK to kill infected cells
CD8 T cells
Infected dendritic cell moves to lymph node and activates the naïve
virus specific T cell response
Antigen primed T cell recognizes MHC molecule and migrates to site
of infection
Effector secreted IFN gamma to kill host cells
o Type II IFN antiviral response
MHC class I peptide complex amplified in numbers by the IFN gamma
release = increased CD8 T cell number
o Before inside cells
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller robbieseal. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $10.33. You're not tied to anything after your purchase.
