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Lecture notes Functional Genomics and Reverse Genetics $14.45   Add to cart
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Lecture notes Functional Genomics and Reverse Genetics

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  • Course
  • Functional Genomics and Reverse Genetics
  • Institution
  • The University Of Birmingham (UBir)

Lecture notes with important topics for exam; includes Pest control, Tet-on/Tet-off, Insect transgenics, piggyBac, Transposable element, Transposons, recombinase-mediated cassette exchange, RIDL, etc.

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Document information

  • August 7, 2022
  • 31
  • 2017/2018
  • Class notes
  • Dr matthias soller
  • All classes

Subjects

  • functional genomics
  • reverse genetics
  • pest control
  • insect transgenics
  • piggybac
  • transposable element
  • transposons
  • ridl
  • tet ontet off
  • recombinase mediated cassette exchange

Written for

  • The University of Birmingham (UBir)
  • Unknown
  • Functional Genomics and Reverse Genetics
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Generating new gene functions:
Insect pest control

,Food security: Insect pest control
- One quarter of the food production lost by
diseases and pests
- mass production in monocultures
favors pest insect outbreaks
- globalization: introduction of non-native species

,Insect vectors for deadly
diseases
- insects can spread disease
(insect vector)
- two main routes: via blood-feeding
(e.g. Malaria, Dengue fever, encephalitis,…)
or excretions
- virus (e.g. West Nile fever), bacteria
(e.g. plague, Rickettsia), protozoans (e.g.
plasmodium, trypanosom, Leishmania)

Globalization and climate change:
Geographical spreading of vectors

, Problems with pesticides

- Resistance

- Destruction of non-target organisms
(natural enemies, pollinators, soil arthropods, wild life)

- also toxic to humans

DDT: used in 1940’s and 50’s to ban Malaria and
Typhus, then banned in the Western world due to
genotoxicity to humans and being a reproductive toxin
to many predators e.g. birds and fish. Half life in soil:
up to 30 years

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