PACOP REVIEWER (2017) Organic Medicinal Chemistry Questions and A nswers
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Course
Organic Pharmaceutical Chemistry
Institution
Organic Pharmaceutical Chemistry
PACOP REVIEWER (2017) Organic Medicinal Chemistry
1. The functional group attached to the acyl amino group of the beta-lactam antibiotic is
A. Phenoxyethyl D. Benzyl B. Isoxazoyl E. Methoxyphenyl C. Imidazole
ANS: B
2. Halogen substituents are best placed in what positio...
pacop reviewer 2017 organic medicinal chemistry 1 the functional group attached to the acyl amino group of the beta lactam antibiotic is a phenoxyethyl d benzyl b isoxazoyl e methoxyphenyl
PACOP REVIEWER (2017) Organic Medicinal Chemistry 1. The functional group attached to the acyl amino group of the beta -lactam antibiotic is A. Phenoxyethyl D. Benzyl B. Isoxazoyl E. Methoxyphenyl C. Imidazole ANS: B 2. Halogen substituents are best placed in what position? A. 1,2-substitution D. Both A and B B. 1,3-substitution E. Both A and C C. 1,4-substitution ANS: A 3. This antibiotic is primarily indicated for what type of infection A. Klebsiella D. Staphylococci B. Enterobact er E. Streptococci C. Pseudomonas ANS: D 4. Adding more than 1 chloride atom in the structure confers what modification on the pharmacokinetic profile of the drug? A. Liberation D. Metabolism B. Absorption E. Excretion C. Distribution ANS: C 5. What is the role of chloride atoms in the structure? A. Increase the susceptibility to penicillinase D. Increase the parenteral absorption B. Increase the plasma concentration E. Increase oral absorption C. Acid resistance property ANS: B 6. Preservatives like parabens increase their preservative property by A. Reducing the parent compound D. Substituting the parent compound with a lipophilic group B. Decreasing molecular weight E. Increasing the molecular weight C. Attaching a halogen to t he parent compound ANS: E 7. Sodium pump is an example of A. Enzyme -linked tyrosine kinase receptor D. Gene transcription -linked receptor B. G-protein coupled receptor E. None of the above C. Ion-channel ANS: C 8. This is an approach in drug d iscovery wherein there is already an existing drug that can be used to identify the new lead compound? A. Random Screening D. Biotechnology techniques B. Molecular Docking E. Rational Drug Design C. Parent compound modification ANS: A 9. Azeotropic distillation of benzene is done in what concentration of ethanol? A. 95% D. 99% B. 70% E. 10% C. 50% ANS: D 10. Radical reactions may also proceed using this reagent A. Bromine water D. Sodium oxalate B. Hydrogen peroxide E. Potassium bitartrate C. Nitric acid ANS: B 11. What is the reagent needed for the reaction? A. NaOH/Oxidizing agent D. NaOH/Reducing agent B. CH3Cl/AlCl 3 E. CH3Br/NaNH 2 C. HNO 3/H2SO4 ANS: B 12. The product formed with the reaction is A. Benzyl alcohol D. Xylene B. Phenol E. Anisole C. Benzoic acid ANS: C 13.The reagent needed for the reaction to proceed is __________ A. CH3Br/NaNH 2 D. HNO 3/H2SO4 B. NaOH/Reducing agent E. NaOH/Oxidizing agent C. CH3COCl/AlCl 3 ANS: C 14. The reagent needed for th e reaction to proceed is __________ A. NaOH/Oxidizing agent D. NaOH/Reducing agent B. CH3Br/NaNH 2/NO 2 E. NBS C. H2O/H 2SO4 ANS: D 15. When a carbonyl group reacts with a secondary amine, what will be the resulting product? A. Imine D. Enamine B. Amide E. Secondary amine C. Tertiary amine ANS: D 16. The addition of hydrogen molecule to an alkene is catalyzed by what metal? A. Silver D. Gallium B. Palladium E. Osmium C. Beryllium ANS: B 17. Methoxybenzene is also known as A. Anisole D. Xylene B. Toluene E. Anethole C. Aniline ANS: A 18. Which of the following compounds can be used to synthesize primary alcohol?
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