CVS-ISCHAEMIC HEART DISEASE
Introduction and Definition
Ischaemic heart disease
Pseudonyms-
Coronary Heart Disease (CHD)
Coronary Artery Disease ( CAD)
Most common form of heart disease and the single most important cause of premature death
It is always due to atheroma and associated c...
therapeutic agents used nitrates b blockers calcium channel blockers nifedipine
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CVS-ISCHAEMIC HEART DISEASE
, CVS-ISCHAEMIC HEART DISEASE
• Introduction and Definition
Ischaemic heart disease
• Pseudonyms-
– Coronary Heart Disease (CHD)
– Coronary Artery Disease ( CAD)
• Most common form of heart disease and the single most
important cause of premature death
• It is always due to atheroma and associated complications
particularly thrombosis
• Primary symptom of ischaemic heart disease is angina pectoris
caused by episodes of myocardial ischaemia.
, Coronary Artery Disease:
clinical manifestation
Clinical problem Pathology
• Stable Angina • Ischaemia due to fixed atheromatous
stenosis of one or more arteries
• Unstable Angina • Ischaemia caused by dynamic artery
obstruction of a coronary artery due to
plaque rupture with thrombosis &spasm
Myocardial infarction • Acute occlusion of coronary artery due to
plaque rupture and thrombosis and
Heart Failure myocardial necrosis
Arrhythmia • Myocardial dysfunction due to ischaemia
or infarction
Sudden Death • Altered conduction due to ischaemia or
infarction
• Ventricular arrhythmias ,asystole, or
massive myocardial infarction
, CVS-ISCHAEMIC HEART DISEASE
• Angina pectoris is a term used to describe
discomfort due to transient myocardial
ischaemia
• Angina is a syndrome which include
– Stable angina
– Unstable angina
– Variant or prinzmetals angina
– Silent myocardial ischemia
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