Deze samenvatting bevat hoofdstuk 12 uit het handboek. Het is een korte samenvatting van de processen van de mitose met de verschillende fases en de celcyclus.
, Verdeling chromosomen
1: interfase = duplicatie ter preparatie van celdeling
2: mitose = gekopierd en naar buitenkant gebracht
3: cytokinese = cel splits in 2 dochtercellen
Figure 12.5_3
1 Chromosomes Chromosomal
DNA molecules
Centromere
Chromosome
arm
Chromosome duplication
2
Sister
chromatids
Separation of sister
chromatids
3 Celcyclus
vrij)
• S: chromosomen verdubbelen
• G2: controle + herstel van het nieuwe DNA (aanmaak histonen -> chromatine te kunnen
spiraliseren)(verdubbeling centriolenpaar)
• G0: rustfase (cellen die niet meer delen) (soms gaan ze toch nog naar G1)
• Mitose: kerndeling
• Cytokinese: cytoplasma deling
, Figure 12.7a
10 µm
G2 of Interphase Prophase Prometaphase
Centrosomes Chromosomes Early mitotic Fragments Nonkinetochore
(with centriole (duplicated, Aster of nuclear
spindle microtubules
pairs) uncondensed) Centromere envelope
Profase:
• Chromatine è chromosomen
• Vorming spoelfig. (Trekdraden (=kinetochoren) & steundraden)
• Trekdraden hechten aan centromeer
Metafase:
• Chromosomen -> max. gecondenseerd
• Liggen in evenaarsvlak
Anafase:
• Trekdraden korter
• Zusterchromatiden gescheiden è naar polen
Telofase:
• Spoelfiguur weg
• Chromosomen despiraliseren & decondenseren è chromatinevezels
• Nieuwe kernmembranen & nucleoli
Cytokinese:
• Insnoering cel (ring van actine- & myosinevezels)
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