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Biochemistry Transcription Concept Map
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  • Course
  • Biochemistry
  • Institution
  • Ateneo De Manila University
  • Book
  • Harper\'s Illustrated Biochemistry Thirty-First Edition

Case study book Harper's Illustrated Biochemistry Thirty-First Edition of Victor Rodwell, David Bender - ISBN: 9781259837944, Edition: 31, Year of publication: - (concept map)

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  • August 27, 2022
  • 3
  • 2021/2022
  • Case
  • Dr.
  • A

Subjects

  • transcription
  • biochemistry
  • harpers biochemistry
  • medicine
  • cim
  • cdu
  • ucsm
  • swu phinma
  • transcription biochemistry

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  • Class notes Biochemistry Harper's Illustrated Biochemistry Thirty-First Edition, ISBN: 9781259837944
  • Class notes Biochemistry Harper's Illustrated Biochemistry Thirty-First Edition, ISBN: 9781259837944
  • Class notes Biochemistry Harper's Illustrated Biochemistry Thirty-First Edition, ISBN: 9781259837944
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  • Biochemistry
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DNA: RNA is synthesized
Template strand – read at 3’ to 5’ from 5’ to 3’ end
Coding strand – same sequence as
RNA produces with U in place of T


Biosynthesis of
Requires ATP, GTP, RNA from DNA
CTP, UTP and Mg2+ DNA in form of chromosomes
(more compact) & presence of
histones --- more complicated
TRANSCRIPTION


PROKARYOTES
Catalyzes RNA EUKARYOTES
synthesis

Pol I: synthesizes major
RNA Pol: synthesizes mRNA, rRNA, rRNA precursors
tRNA
Core enzyme – α2ωββ’
Holoenzyme – α2ωββ’σ RNA Polymerase Pol II: synthesizes
σ subunit recognizes promoter mRNA precursors


Most extensively studied
α – assembles enzyme, recognizes
GTFs
ω – restores denatured RNA pol First base Region of Pol III: synthesizes
ββ’ – combine to form active site
incorporated to template strand tRNA, 5S rRNA, small
σ – recognizes promoter
RNA chain: +1 to which RNA precursors
position, TSS polymerase
binds

Pribnow box: -10 region
Core promoter: -35 element TATA box: -25; TATAAAA
or region Promoter GAAT box: -80; GGCCAATCT
Extended promoter: UP GC box: variable; GGGCGG
element (-40 to -60)


Consensus
Upstream: - sequence - shows Promoter – rich in AT
Downstream: + the nucleotides with 2 H-bonds only
σ recognizes promoter; bridging most commonly
core promoter to RNA pol; found at each
closed complex is formed Most studied position
and Formation of preinitiation
controlled
complex, which normally
σ initiates separation of DNA contains Pol II and general TFs
strands; open complex is
formed
TFIID recognizes TATA box;
Initiation TFIIA binds and interacts with
DNA and TFIID; TFIIB binds
bridging BP and Pol II; TIIF
β and β' bind to ssDNA; ATP or binds to Pol II to suppress
Transcription
GTP (first RNA base) binds to nonspecific binding; TFIIE
factor – regulating
TSS (+1 position) interacts with
protein but not a unphosphorylated Pol II; TFIIH
part of RNA pol exhibits helicase activity

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