NR-565 Advanced Pharmacology Fundamentals Week 2 & 3 Midterm Exam Study Guide Why types of pain can be treated by psychotropic medications: Anticonvulsants ✓ Neuropathic pain Select anticonvulsants that can treat pain ✓ Pregabalin ✓ Gabapentin ✓ Carbamazepine Why types of pain can be treated by psychotropic medications: Antidepressants ✓ Neuropathic pain ✓ Migraine Select antidepressants that can treat pain ✓ Tricyclics (TCA) ✓ SNRI s Which of the following is NOT a potential harm/risk of pregabalin? Select the best answer. a) Sedation b) Gastrointestinal bleeding c) Dizziness d) Ataxia Alan Sayed has neuropathic pain. What nonopioid medications should be considered for his treatment? Select all that apply. a) Tricyclic antidepressants ( TCAS ) b) Topical lidocaine c) Serotonin and norepinephrine reuptake inhibitors ( SNRI s) d) Gabapentin Should statins be used during pregnancy? ✓ No, because they have known teratogenicity When should statins be avoided ✓ During pregnancy and when muscle damage has occurred What population is warfarin not indicated for use in and why ✓ Pregnant women because it can cross the placenta and affect the developing fetus causing fetal hemorrhage and death or it can cause malformations, CNS defects, and optic atrophy What blood pressure medications are okay for use in pregnant women ✓ Labetolol ✓ Methyldop a What is the concern with blood pressure medication in pregnancy ✓ BP should not be treated aggressively in pregnancy because drop in BP can compromise uteroplacental blood flow How to determine therapeutic effect of warfarin ✓ Assess PT/INR Warfarin antidote ✓ Vitamin K Warfarin drug interactions ✓ Increased effect with: a. Alcohol b. Nonsteroidal anti-inflammatory drugs ( NSAIDS ) c. Diuretics d. Selective serotonin reuptake inhibitors ( SSRIS ) e. Antidepressants f. Steroids g. Antibiotics h. Vaccines i. Vitamins (e.g., vitamin K). Therapeutic range of carbamazepine ✓ Narrow therapeutic index
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