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Samenvatting Hoofdstuk 6 Glycogeenmetabolimse
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Hoofdstuk 6 Glycogeenmetabolimse van Metabolisme en metabole regeling van Johan Van Lint.
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vrijdag 22 april 2022H6. Glycogeenmetabolisme
1. Algemene inleiding op glycogeenmetabolisme
Mens leven = cte bron glucose in bloed
Bloedglucose uit
• Voeding
• Afbraak glycogeen
• Gluconeogense
2. Structuur en functie van glycogeen
°Structuur glycogeen
=homolytische sacharide + vertake
ketens uit α-D-glucose
° Hoeveelheden en rol van glycogeen in de lever en de spier
Belangrijksre voorraden glycogeen in skeletspieren & lever
Rol spierglycogeen = brandstofreserve: synthese ATP tijdens spiercontractie
Leverglycogeen = in stand houden bloedglucoseconc
° Schommelingen in de glycogeenvoorraaden
Goed gegeten: leverglycogeenvoorraad stijgt
Vasten : daalt
Spierglycogeen hier niet echt door beïnvloedt
gesynth => spiervoorraden aanvullen na vb spierinspanning
3. Synthese van glycogeen
Gesynth uit moleculen α-D-glucose in cytosol en ATP & UTP nodig
° Synthese van UDP-glucose
UDP-glucose gesynth uit glucose-1-fosfaat & UTP
—> UDP-glucosepyrofosforylase
° Synthese van een primer voor glycogeensynthase (‘glycogenin’)
Maakt afa-1,4-bindingen in glycogeen
Enkel bestaande ketens glucose verlengen
Glycogin = acceptor glucoseresidu’s bij afwezigheid glycogeenfragment
Glycogeeninitiatorsunthase
1 Metabolisme en metabole regeling Julie De Wit
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