Dit document bevat de definitieve versie van de ConceptMap (CMap), inclusief alle pathways (Controle van de celcyclus, Wnt-pathway, RTK-pathway, TGFβ-pathway, Apoptose pathway, Metastase- en angiogenese pathway).
Growth factors
Hormones
activatie
FAS
bindt
Bindt
HIF
Receptor Autofosforylatie
Death Receptor
Fas Tyrosine Kinase
activatie
stimuleert productie
Bindt
bindt
VEGF-A
Intrinsieke factoren,
Wnt zoals DNA-schade
FADD
bindt Grb2 bindt
VEGFR bindt Af
Bindt activatie
Bindt
BH3 (PUMA
BCl-2 Sos
en NOXA) DED
EMT
Frizzled zorgt voo
Bindt
katalyseert
MMP's zorgen voor
BAX BAK uitwisseling
LRP GDP naar
5/6 MOMP
Pro-caspase-8 Pro-caspase-10 GTP
Knippen BID GTP uitwisseling GDP
tot tBID SRC
Signaal- Klieving Klieving
overdracht Mitochondrium bindt inactief als gekoppeld met
stimuleert aanmaak
Caspase-8 Caspase-10 Ras bindt PI-3 Kinase
Komt vrij Komt vrij PLCG1 maakt IP3
Bindt
Vorming
fosforyleert
Dishevelled SMAC laat vrij
Cytochroom-C Raf/MAPKKK maakt maakt DAG
fosforyleert PIP2 Ca2+
Bindt aan DISC activeert
Kinase 1 XIAP
lex produceert
mp
APAF-1 MEK 1 & 2 / stimuleert aanmaak
sco PKC-β
iging Pro-caspase-3 Klieving Caspase-3 MAPKK
et
rni APC
Ve bindt PIP3 bindt
Bindt aan fosforyleert eNOS
Axine
GSK-3
Pro-caspase-9 Omzetting
Caspase-9 Apoptose ERK 1/2/ PKC PDK1 activeert
fosforyleert
Apoptosoom
MAPK Fofsforyleert
Afname NO stimuleert
Pro-caspase-7 Klieving Caspase-7
fosforylering en
fosforyleert
degradatie Akt
Fosforyleert Fos Jun
Bèta- Celgroei en
zorgt voor
zorgt voor
katenine Hoopt op, bindt Laat los
celproliferatie MDM2
fosforyleert
Bindt
en vervangt Gr
P21 Cycline A Cds 2 ORC
Ubiquitinylatie
Codeert voor LEF/ Gr Codeert voor
Codeert voor
P15 P15 TCF P53 P53
Fosforyleert
Inhibeert cMyc S-Cdk
Stimuleert P21 Cdc6
transcripte Codeert voor
Transcriptie Rb
G1/S-Cdk
CMYC Bindt
Fosforyleert
SMAD 2 Spoelfiguur
SMAD 4 niet in orde?
of 3 Cycline Bindt
M-fase G1-fase E2F
E Cdk 2 Spindle
checkpoint transcriptie
Bindt
Cdk 4/ milieu
cycline D aan
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