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MGZ Q4 Aanval en verdediging

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Alle aantekeningen die in kwartaal 4 van MGZ gemaakt zijn. Inclusief e-learnings en belangrijke punten uit ZSO's zijn erin verwerkt.

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  • September 21, 2022
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  • 2020/2021
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MGZ: aanval en verdediging
Kwartaal 4




https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178865/

https://assets.uzleuven.be/files/2019 -12/Immuunsysteem.pdf

,Inhoud
Immuunsysteem als netwerk (MIN) ........................................................................................................ 4
Hoorcollege: het immuunsysteem als netwerk .................................................................................. 4
Thymus ............................................................................................................................................ 4
E-learning: introductie immunologie .................................................................................................. 7
Aangeboren immuunrespons .......................................................................................................... 7
Verworven immuunsysteem ........................................................................................................... 9
E-learning: normale hematopoëse .................................................................................................... 11
Werkgroep: immuunsysteem -> bekijk powerpoint ......................................................................... 14
Teksten uit Junqueira ........................................................................................................................ 18
B-lymfocyt: .................................................................................................................................... 18
T-lymfocyt:..................................................................................................................................... 19
Lymfeknopen ................................................................................................................................. 20
Practicum voorbereiding: anatomie lymfatische systeem ................................................................ 20
Micro-organismen en antimicrobiële therapie (MAT) .......................................................................... 22
Ziektelast en transmissie van infectieziekten.................................................................................... 22
Virale infectie en therapie ................................................................................................................. 23
Eigenschappen van micro-organismen en pathogenese van bacteriële infecties ............................ 27
Antibacteriële therapie en resistentie .............................................................................................. 28
Antibacteriele therapie (antibiotica) ................................................................................................. 30
Antibacteriële resistentie .................................................................................................................. 31
QUIZ ................................................................................................................................................... 33
Stranger danger (MSD) .......................................................................................................................... 34
Hoorcollege: vreemd en/of gevaarlijk? ............................................................................................. 34
Herkenning van het immuunsysteem wie, wat, waar ....................................................................... 34
Ontsnapping aan het immuunsysteem ............................................................................................. 34
Meet the expert ................................................................................................................................ 35
E-learning: overzicht immuunsysteem .............................................................................................. 36
MGZ meets CSI (MCC) ........................................................................................................................... 38
Schade en herstel (MSH) ....................................................................................................................... 39
Hoorcollege: inleiding........................................................................................................................ 39
Onsteking: acuut en chronisch .......................................................................................................... 39
Ontsteking systemische..................................................................................................................... 40
Wondgenezing................................................................................................................................... 41
Afsluitend RC ..................................................................................................................................... 42
Sturing van het immuunsysteem (MSR) ................................................................................................ 43

, Inleidend hoorcollege........................................................................................................................ 43
Immunotherapie bij kanker ............................................................................................................... 43
The use of biological antibodies in inflammatory disease ................................................................ 44
Vaccines and infectious diseases....................................................................................................... 45
Vormen meningen of alternatieven .................................................................................................. 45
Balans (MBA) ......................................................................................................................................... 48
Inleidend hoorcollege........................................................................................................................ 48
Hyperreactie ...................................................................................................................................... 49
Hyporeactiviteit ................................................................................................................................. 50

, Immuunsysteem als netwerk (MIN)
Hoorcollege: het immuunsysteem als netwerk
Inflammatie= ontsteking door lichaamsvreemde. Warmte, roodheid, zwelling, pijn en verlies van
functie

De huid, mucosa (ogen, neus, longen en darmen) zijn de eerste beschermers van het lichaam. Door
mechanische barrière en chemische barrière (maagzuur/ enzymen/ microbioom).

Aangeboren: uren

Verworven: dagen

Antilichamen en complement (faciliteert de opname door fagocyten) zijn opgeloste componenten.

T-cellen -> herkenning

B-cellen -> antilichamen maken



Primaire lymfeorganen= waar de bloedcellen gemaakt worden. Thymus, beenmerg. Thymus wordt
kleiner zodra je ouder worden (leidt T-cellen op).

Secundaire lymfeorganen= lymfeknopen, milt, mucosa (speciale cellen)




Figuur 1: differentatie van bloedcellen

Thymus
Alleen T-cellen komen hierin terecht. Ze worden hier opgeleid in herkennen van vreemde antigenen.
1/100 T-cellen slagen. Er wordt getest of ze een functionele membraan receptoren (CD3) hebben.
Elke T-cel heeft zijn eigen specifiek receptor (voor elke vreemde antigeen een andere). Eerste
positieve selectie: kan CD3 actief worden. Daarna negatieve selectie: reageert het niet op eigen
peptide. Tijdens dit proces krijgt het ook CD4 (helper T-cellen) of CD8 (cytotoxische T-cellen). Slagen
ze niet voor een van de selecties gaat hij dood.

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