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NR546 Antidepressant and Mood Stabilizer Medication Table
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Name Indication, starting dose, target symptoms, and affected neurotransmitters Half-life (T1/2) CYP450 enzyme Notes/Notable side effects/Precautions SSRIs Citalopram (Celexa) Indication  Depression  PMDD  OCD  Panic d/o  GAD  PTSD  Social anxiety d/o Neu...

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  • September 22, 2022
  • 12
  • 2022/2023
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Antidepressant Medications
Name Indication, starting dose, target symptoms, and affected neurotransmittersHalf-life (T1/2)
CYP450 enzymeNotes/Notable side effects/Precautions
SSRIs Citalopram (Celexa) Indication
Depression
PMDD
OCD
Panic d/o
GAD
PTSD
Social anxiety d/o
Neurotransmitter
Serotonin
Target symptoms
Depressed mood
Anxiety
Panic attacks, avoidant behavior, reexperiencing, hyperarousal
Sleep disturbance, insomnia and hypersomniaHalf-life
23-45 hour
CYP450
Weak inhibitor of CYP450 2D6
Metabolized by CYPf450 3A4 and 2C19Sexual dysfunction
Decreased appetite, n/d, constipation, dry mouth
Dose dependent insomnia, sedation, agitation, tremors, headache,dizzy
Pt with bipolar or psychotic d/o may be more vulnerable to CNS-activating actions of SSRIs
Sweating
Bruising and rare bleeding
Rare hyponatremia
Syndrome of inappropriate antidiuretic hormone secretion
Rare seizures, induction of mania, activation of suicidal ideation
Escitalopram (Lexapro) Indication
MDD 12+
GAD
Panic d/o
OCD
PTSD
Social anxiety d/o
PMDD
Neurotransmitter
SerotoninHalf-life
27-32 hours
CYP450
Substrate for CYP450 and 3A4
No significant actions
on CYP450 enzymesSexual dysfunction ED, delayed ejaculation, decreased
sexual desire, anorgasmia
Decreased appetite, n/d, constipation, dry mouth
Insomnia and sedation, agitation, tremors, headache, dizzy
Pt with bipolar or psychotic d/o may be more vulnerable to CNS-activating actions of SSRIs
Sweating
Rare hyponatremia
Syndrome of inappropriate antidiuretic hormone Target symptoms
Depressed mood
Anxiety
Panic attacks, avoidant behavior, reexperiencing, hyperarousal
Sleep disturbance, insomnia and hypersomniasecretion
Rare seizures, induction of mania, activation of suicidal ideation
Fluoxetine (Prozac) Indication
MDD 8+
OCD 7+
PMDD
Bulimia nervosa
Panic d/o
bipolar depression used with olanzapine
treatment resistant depression used with olanzapine
social anxiety d/o
PTSD
Neurotransmitter
Serotonin NE
DA
Target symptoms
Depressed mood
Energy, motivation, and interest
Anxiety (can increase anxiety Half-life
Active metabolite 2 week
Parent drug 2-3 d.
CYP450
Inhibits CYP450 2D6
Inhibits CYP450 3A4Sexual dysfunction ED, delayed ejaculation, decreased
sexual desire, anorgasmia
Decreased appetite, n/d, constipation, dry mouth
Insomnia and sedation, agitation, tremors, headache, dizzy
Pt with bipolar or psychotic d/o may be more vulnerable to CNS-activating actions of SSRIs
Sweating
Bruising and rare bleeding
Syndrome of inappropriate antidiuretic hormone secretion
Rare seizures, induction of mania, activation of suicidal ideation

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