Who is ACE and why do we want to inhibit him? Correct Answer: ACE
is the enzyme that converts angiotensin 1 to angiotensin 2. angiotensin 2
in a round about way causes vasoconstriction and increase the blood
pressure
What are 6 things ACE inhibitors ("prils") good for? Correct Answer: 1.
Anti-hypertensive agent via vasodilation and inhibition of aldosterone
(Na+ and H20 diuresis)
2. Treatment of heart failure by inhibiting renin-angiotensin- aldosterone
—CHF is a HYPER-RENINEMIC state
3. Anti-inflammatory
4. Anti-thrombotic
5. Hypoglycemic (be careful when starting ACE inhibitors in diabetics)
6. Decrease growth of tissues or "remodeling"
, How do "sartans" work? Correct Answer: angiotensin receptor blockers
(bypass ACE) and work by blocking the angiotensin-2 receptors on
tissues
Olol, alols and ilols are what? Correct Answer: beta blockers
explain Beta 1 Correct Answer: found on heart muscle; epinephrine
binds to beta 1 and increase heart rate and strength of contraction
(chronotropic and inotropic)
explain beta 2 Correct Answer: skeletal muscle (tremor), bronchioles of
the lungs (bronchodilation), large arteries of the legs (vasodilation),
piloerection (hairs stand up on back of neck and arms)
why not just use beta 2 blockers? Correct Answer: can cause
bronchoconstriciton and exacerbate COPD asthma as well as
vasoconstrict the femoral artery
T/F Beta Blockers are considered first line therapy for essential
hypertension Correct Answer: F: not considered first line
What are "dipines"? Correct Answer: peripheral vessel calcium channel
blockers
What are clinical uses of the "dipines" Correct Answer: hypertension
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