Samenvatting van het volledige vak farmacologie dus zowel partim I & II (behaald resultaat 19/20) aan de hand van flash cards
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Course
Farmacologie
Institution
Universiteit Antwerpen (UA)
Samenvatting van het volledige vak farmacologie dus zowel partim I & II (behaald resultaat 19/20) aan de hand van flash cards: Dit bevat een uitgebreide samenvatting van Farmacologie gegeven door professor Pieter-Jan Guns & professor Guido De Meyer. De samenvatting bevat al de lessen (deel 1 & 2), ...
Charlotte Plessers (s0172911) – 3e BA GEN (2019-2020)
Geneesmiddelen – partim 1
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,Charlotte Plessers (s0172911) – 3e BA GEN (2019-2020)
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,Charlotte Plessers (s0172911) – 3e BA GEN (2019-2020)
5-hydroxytryptamine
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, Charlotte Plessers (s0172911) – 3e BA GEN (2019-2020)
5-hydroxytryptamine = 5-HT = serotonine
Biosynthese & metabolisme:
- Synthese uit L-tryptofaan.
- Afbraak door MAO en aldehyde dehydrogenase tot 5-HIAA.
Classificatie van 5-HT-R (zie H7):
- 7 hoofdtypes (5-HT1-7)
- Type 1 en 2 zijn onderverdeeld in subtypes
Fysiologische effecten:
- GIS: motiliteit, braakreflex
- Bloedplaatjes: opname 5-HT (plasmaconcentratie), vrijgesteld bij aggregatie + zorgt
voor activatie van TRC
- Bloedvaten: VC (via 5-HT1B/1D) of VD (via 5-HT2), rol bij controle van microcirculatie
- Nociceptie: activatie pijngevoelige zenuwen + pijnperceptie in CZS (5-HT3)
- CZS: excitatie (via 5-HT2) of inhibitie (via 5-HT1A), betrokken bij eetlust/stemming/
slaap/hallucinaties/braken/stereotiep gedrag, rol bij depressie
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