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Cell Biology 2018 Exam Paper
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Cell Biology 2018 Exam Paper
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IMPERIAL COLLEGE LONDONB.Sc. Examination 2018
This paper is also taken for the relevant examination for the Associateship of the Royal
College of Science
INTEGRATIVE CELL BIOLOGY
Monday 18 June 2018 10.00 - 13.00
FOR SECOND YEAR STUDENTS IN BIOCHEMISTRY AND BIOTECHNOLOGY
Answer any THREE questions. Answer each question in a separate book. Parts of a
question carry equal weighting unless otherwise specified.
1. Addition of epidermal growth factor (EGF) to cells expressing the EGF receptor
leads to transcription of the early response gene c-fos. Describe the full
sequence of events that link growth factor binding to target gene transcription.
2. You are studying a hormone that acts through a G protein-coupled receptor
(GPCR). Adding the hormone to cells expressing its receptor results in
oscillations of intracellular [Ca2+]. Propose a mechanism that explains this
behaviour and discuss how the [Ca2+] oscillations may ultimately lead to
phosphorylation of effector proteins.
3. How strong is the evidence that Alzheimer’s and Parkinson’s disease are caused
by prion-like mechanisms?
4. Discuss fast and slow neurotransmission and the different roles they have in the
nervous system.
5. Why do we need different functional classes of CD4 T cells? Describe their roles
in adaptive immune responses.
6. Define what a stem cell is (15%). Discuss how stem cells can be used to learn
more about disease mechanisms and how they might be used as disease
treatments (85%).
End of paper
© Imperial College London
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