Summary
Summary Diabetes & Vessel Function -- Heart Failure & Therapy
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Summary of the Diabetes & Vessel function lecture in the Heart Failure and Therapy course
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13 . Diabetes & Vessel FunctionMicrovascular Research is the narrowing of the small blood vessels that branch off the
& send 02 Rich blood to
coronary Artery
Heart muscle This important site
.
is An
for pressure Dissipation and therefore ,
peripheral vascular Resistance .
Diabetes & cub is A global problem .
Diabetes RELATED
-
Loss of Life primarily Due
to vascular complications .
The probability
of survival when having Diabetes is lower
Than no Di Ab .
There are 4 complications when having ☐ inb.:
-
2✗ to ↳ × increase in CVD
mortality .
- LebDing cause of New cases of enb Stage
Renal Disease .
-
Leading cause of new cases of blindness in
ADULTS .
-
Leading cause of non - traumatic Lower
extremity amputations .
The impairment of MYOCARDIAL blood flow is
present before onset of TZD It compares .
Different stages of Diabetes with MYOCARDIAL
blood flow Flow reserve is MEASURED AND
.
On TZD, MYOCARDIAL flow Reserve is Lower .
Furthermore, A COLD pressure test is Done
,
Which Decreases As well .
A Reduced MICROVASCULAR BLOOD Flow
impairs
metabolism & organ function This . risks of getting
Diabetes etc .
Lack of Activity , FOOD pattern genetics AS A cause ,
of arteriole Dysfunction The Different stimuli are.
integrated to Determine perfusion This Determines
.
functioning of brain •Heart & muscles .
, The endothelial cell can modulate the functioning of cardiomyocytes They are triggered by
.
the occurrence of comorbidities One .
function
of endothelium is the secretion of
VASODILATOR RADICAL (NO) This can Dilate
blood vessels & RELAX CARDiomyocyte .
When considering the endothelial contrib .
to Heart failure, you have to remember
that majority of total surface of endothelium
9 Relistionship
is in your capillaries
Carpio myocytes microvascular function .
TNF ✗ impairs the benificinl effect of CARDIAC microvascular endothelial cells on
cardiomyocytes
-
& contraction Relaxation
Mic was .
properties Also predict CVD .
Activating eNos (endothelial NO )
synthase is important for maintaining A
normal vessel tone & organ blood flow This .
Activation is Due to co factor cat
- that binds
to ENOS This.
is increased
by ion channel
Activating Agonist It . can Also be Due to
phosphorylation by kinases .
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