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HC Pathofysiologie & veroudering
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HC Pathofysiologie & veroudering
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HC Pathofysiologie & verouderingWe worden ouder, maar niet in goede gezondheid. Steeds meer multimorbiditeit.
Bij kinderen vooral:
- Astma
- Allergie
Grote heterogeniteit onder ouderen:
- Succesvolle veroudering: vrouwen zoals Hendrikje van Andel en Queen Elizabeth, of het
hardloop koppel die op 80 jarige leeftijd een marathon lopen.
- Verlies van pigment en elastine
- Afname reservecapaciteit van organen
- Lever en nier: veranderd e ect medicijnen (verminderde klaring)
- Brein: Werkgeheugen minder, multitasken moeilijker
- Cardiaal en pulmonaal: minder uithoudingsvermogen
- Afname spiermassa en toename vetmassa
- Afname botmineraal dichtheid
- Eiwitstapeling in ooglens (cataract)
- Verminderde accommodatie (leesbril)
- Presbyacusis (verlies hoge tonen)
- Hypertensie (arteriele vaatstijfheid)
- Wat hoort niet bij succesvolle veroudering? —> Ziekte
Wat is veel voorkomende of ‘normale’ veroudering maar zijn eigenlijk ziekte?
- Verworven aandoeningen:
- COPD —>
- DMII —> Sterven eilandjes van Langerhans —> Schade aan vaten door Maillard reactie
- Artrose
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